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Increasing evidence indicates that further exploration of cellular quality control system is critical for understanding the basic mechanism underlying neurodegenerative disorders including amyotrophic lateral sclerosis, Parkinson’s disease and Alzheimer’s disease. The goal of our studies is to describe how protein, organelle and membrane-less organelle quality control systems, including ubiquitin-proteasome system, autophagy and biomolecular phase separation machinery, fail to protect neurons at disease stages. To this end, we will use cell biology, molecular biology, biochemical approaches and genetic manipulation of animal models to investigate the relationship between these quality control systems and neurodegeneration.
Increasing evidence indicates that further exploration of cellular quality control system is critical for understanding the basic mechanism underlying neurodegenerative disorders including amyotrophic lateral sclerosis, Parkinson’s disease and Alzheimer’s disease. The goal of our studies is to describe how protein, organelle and membrane-less organelle quality control systems, including ubiquitin-proteasome system, autophagy and biomolecular phase separation machinery, fail to protect neurons at disease stages. To this end, we will use cell biology, molecular biology, biochemical approaches and genetic manipulation of animal models to investigate the relationship between these quality control systems and neurodegeneration.
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论文共 53 篇作者统计合作学者相似作者
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Shiqiang Xu, Qilian Ma, Junwen Shen,Ningning Li, Shan Sun,Nana Wang, Yang Chen,Chunsheng Dong, Kin Yip Tam, Jochen H.M. Prehn,Hongfeng Wang,Zheng Ying
Acta Pharmaceutica Sinica Bno. 5 (2024): 2026-2038
Ningning Li, Lingling Rao, Xueqing Zhao, Junwen Shen, Dan Su,Guoqiang Ma,Shan Sun, Qilian Ma,Li Zhang,Chunsheng Dong,Kin Yip Tam,Jochen H M Prehn,
Frontiers in Cell and Developmental Biology (2023): 1266198
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Qilian Ma, Jiaqi Xin, Qiang Peng,Ningning Li,Shan Sun,Hongyu Hou,Guoqiang Ma,Nana Wang,Li Zhang,Kin Yip Tam,Heiko Dussmann,Jochen H. M. Prehn,
EMBO REPORTSno. 9 (2023): e55859-e55859
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Nature Communicationsno. 1 (2023): 4172-17
Advanced drug delivery reviews (2023): 115025-115025
Fundamental Researchno. 5 (2022): 807-816
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