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Accuracy is a remarkable feature of a large number of biological processes. To maintain homeostasis, cellular protein degradation must be carried out with no less efficiency or precision than transcription and translation. My lab is trying to understand how the cell achieves accurate control of protein degradation and how its failure may lead to neurodegeneration and aging. Using modern enzymological techniques, namely single-molecule fluorescence/force spectroscopy and cryo-electron microscopy, we are investigating how the information in ubiquitin configurations is decoded by the proteasome, a universal protein machine in eukaryotic species, to command an accurate rate of protein degradation.
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论文共 52 篇作者统计合作学者相似作者
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Jiangtao Zhang,Chunhua Zhan,Junping Fan, Dian Wu,Ruixue Zhang,Di Wu, Xinyao Chen,Ying Lu,Ming Li, Min Lin,Jianke Gong,Daohua Jiang
bioRxiv : the preprint server for biology (2023)
STAR Protocolsno. 4 (2023): 102182-102182
biorxiv(2023)
Molecular cellno. 16 (2023): 2829-2831
bioRxiv : the preprint server for biology (2023)
Louis Colson,Youngeun Kwon, Soobin Nam, Avinashi Bhandari, Nolberto Martinez Maya,Ying Lu,Yongmin Cho
Ka Ying Sharon Hung,Sven Klumpe,Markus R. Eisele,Suzanne Elsasser, Geng Tian,Shuangwu Sun,Jamie A. Moroco,Tat Cheung Cheng, Tapan Joshi, Timo Seibel,Duco Van Dalen,Xin-Hua Feng,
Nature Communicationsno. 1 (2022): 1-13
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