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个人简介
Professor Ying Hu’s laboratory mainly focused on cancer biology specifically in the field of proto-oncogene and tumor suppressor’s functions. p53 is the most frequently-mutated gene in human tumors. Over 50% of all tumors and almost every type of tumor contain p53 mutations, whereas wild type p53 tumors are often accompanied with the defects in p53 signaling components. No doubt, revealing p53’s functions and its regulatory mechanisms is critical for understanding the molecular mechanisms of oncogenesis. Dr. HU’s research interest is to investigate p53 signaling and particularly to dissect the interactions of p53 family members with other upstream regulatory proteins, such as ASPPs. Her group is focused on the translational and posttranslational regulatory mechanisms of ASPPs. Another paradigm of their work is to reveal p53-independent biological functions of ASPPs. The research in the lab is carried out at molecular and cellular levels using both cancer cells models and clinical human cancer tissue samples. The methods and technologies used in her current lab include in vitro cell culture, MTT, Western Blotting, FACS, RT-PCR, molecular cloning, soft agar assay and many other molecular and cellular tools. The goal of laboratory is to develop clinically relevant biomarkers and therapeutic targets for human malignancy diseases.
研究兴趣
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PARTICLE & PARTICLE SYSTEMS CHARACTERIZATIONno. 1 (2016): 53.0-62.0
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