基本信息
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职业迁徙
个人简介
2003-2005南京大学医药生物技术国家重点实验室博士后生化与分子生物
2006-南京大学生命科学学院副教授、硕士生导师
2006南京大学青年骨干教师培养对象
2009中国药理学会“施维雅”青年药理学工作者奖2009法国驻华领事“优秀科技创新”人才奖
研究方向
生化与分子药理学、细胞生物学、生物化学与分子生物学
1:钠钾ATP酶及其配体的新生物学功能研究
Na,K-ATPase is a ubiquitous ion pump across membrane, in recent years, increasing evidence reveals that besides ion-pumping activity, this ion transporter is also actively involved in many patho-physiological regulation via multiple signaling pathway. Furthermore, the endogenous Na,K-ATPase inhibitors are separated and identified from human serum or urine, but the biological function of these active components remains elusive. Our current project is to explore the novel biological function of Na,K-ATPase as well as its inhibitors in cancer or inflammation.
2:炎症因子mRNA转录后水平调控机制及其在药物筛选中的应用价值
The post-transcriptional regulation of inflammatory cytokines plays a critical role in a variety of immune regulation, which allows the cells to elaborately control the progression of immune reaction. Many strategies are adopted by cells to regulate cytokines mRNA turnover, such as miRNA or RNA binding proteins (RBPs).Among them, we pay special attention to RBPs such as HuR, and try to uncover the novel function of these RBPs in controlling cytokines mRNA turnover. We are also interested in the special intercellular organelles that are responsible for mRNA reprogramming. Based on these mechanisms, we expect to screen anti-inflammatory herbal medicine extracts , and to identify new chemicals and novel mechanisms.
3:小分子抗肿瘤或增敏剂活性物质的寻找与机制研究
It has long been recognized that not all cancer cells are sensitive to a certain chemotherapeutic drug, such as As2O3. In view of this deficiency, to increase tumor cells sensitivity towards anti-tumor drugs has become a heat topic. We show great interest in looking for small molecules that can significant increase cancer cells sensitivity towards tumor-targeting drugs from the library of the nature products, and expect to identify the promising drug target for cancer therapy.
4: 中药抗肿瘤分子药理学
The herbal medicine has made great contribution to the discovery of new anti-cancer drug. Recently, many chemicals for herbal medicine have shown significant anti-tumor effect, but the molecular mechanisms remain not fully understood. On this project, we expect to identify the mechanisms of some of these natural products by multiple molecular as well as cellular approaches.
2006-南京大学生命科学学院副教授、硕士生导师
2006南京大学青年骨干教师培养对象
2009中国药理学会“施维雅”青年药理学工作者奖2009法国驻华领事“优秀科技创新”人才奖
研究方向
生化与分子药理学、细胞生物学、生物化学与分子生物学
1:钠钾ATP酶及其配体的新生物学功能研究
Na,K-ATPase is a ubiquitous ion pump across membrane, in recent years, increasing evidence reveals that besides ion-pumping activity, this ion transporter is also actively involved in many patho-physiological regulation via multiple signaling pathway. Furthermore, the endogenous Na,K-ATPase inhibitors are separated and identified from human serum or urine, but the biological function of these active components remains elusive. Our current project is to explore the novel biological function of Na,K-ATPase as well as its inhibitors in cancer or inflammation.
2:炎症因子mRNA转录后水平调控机制及其在药物筛选中的应用价值
The post-transcriptional regulation of inflammatory cytokines plays a critical role in a variety of immune regulation, which allows the cells to elaborately control the progression of immune reaction. Many strategies are adopted by cells to regulate cytokines mRNA turnover, such as miRNA or RNA binding proteins (RBPs).Among them, we pay special attention to RBPs such as HuR, and try to uncover the novel function of these RBPs in controlling cytokines mRNA turnover. We are also interested in the special intercellular organelles that are responsible for mRNA reprogramming. Based on these mechanisms, we expect to screen anti-inflammatory herbal medicine extracts , and to identify new chemicals and novel mechanisms.
3:小分子抗肿瘤或增敏剂活性物质的寻找与机制研究
It has long been recognized that not all cancer cells are sensitive to a certain chemotherapeutic drug, such as As2O3. In view of this deficiency, to increase tumor cells sensitivity towards anti-tumor drugs has become a heat topic. We show great interest in looking for small molecules that can significant increase cancer cells sensitivity towards tumor-targeting drugs from the library of the nature products, and expect to identify the promising drug target for cancer therapy.
4: 中药抗肿瘤分子药理学
The herbal medicine has made great contribution to the discovery of new anti-cancer drug. Recently, many chemicals for herbal medicine have shown significant anti-tumor effect, but the molecular mechanisms remain not fully understood. On this project, we expect to identify the mechanisms of some of these natural products by multiple molecular as well as cellular approaches.
研究兴趣
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JOURNAL OF COLLOID AND INTERFACE SCIENCE (2024): 825-833
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Frontiers in oncology (2023): 1160342
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