基本信息
浏览量:21
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
个人简介
My research interests involve developing high throughput technology to identify regulatory elements in the human genome and validating the biological relevance of these elements. In my graduate study, I focused on a cancer hallmark signal pathway in lung cancer, NRF2, and obtained expertise in investigating drug sensitivity, gene interactions, and high throughput sequencing data analysis. I am excited about uncovering the feedback regulations between NRF2 factor and KEAP1 promoter in human lung cancers and the possibility of taking advantage of this regulation in deciding lung cancer patient prognosis. In my postdoctoral research, My focus has been shifted to functional characterization of genetic variants. To determine functional SNPs, I developed both experimental and analytical methods to dissect regulatory SNPs. Through CRISPRi screening and sQTL analysis, we identified multiple innovative functional SNPs in prostate cancer. We characterized several candidate SNPs and target genes and unveiled fresh insights into their oncogenesis mechanisms. I look forward to continuing my contribution to understanding prostate cancer genetics by using high throughput technologies.
研究兴趣
论文共 72 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
bioRxiv : the preprint server for biology (2024)
Nature Communicationsno. 1 (2024): 1-20
Si-Chen Di,Wen-Jin Chen,Wei Yang,Xiang-Min Zhang,Ke-Qin Dong,Yi-Jun Tian,Ye Sun, Cheng Qian,Jia-Xin Chen, Zi-Chang Liu, Zi-Xuan Gong,Jian Chu,
Cell death & diseaseno. 7 (2024): 533-533
INTERNATIONAL JOURNAL OF MEDICAL SCIENCESno. 3 (2024): 496-507
Taylor Peak,Yijun Tian, Aman Patel, Tim Shaw,Alyssa Obermayer,Jose Laborde,Youngchul Kim,Joseph Johnson,Paul Stewart,Bin Fang,Jamie K. Teer,John Koomen,
Laboratory investigationno. 5 (2024): 102041-102041
Journal of biomolecular structure & dynamicspp.1-18, (2023)
International journal of molecular sciencesno. 3 (2023): 1830-1830
Yijun Tian,Dandan Dong,Zixian Wang,Lang Wu,Jong Y Park,Gong-Hong Wei,Liang Wang, PRACTICAL/ELLIPSE consortium
Xingang Cui,Hongru Wang,Yijun Tian,Jian-Min Lv,Xiaokai Shi, Yongbing Sun, Cheng Qian,Song Xu,Sishun Gan
Research Square (Research Square) (2023)
加载更多
作者统计
#Papers: 70
#Citation: 1374
H-Index: 17
G-Index: 37
Sociability: 6
Diversity: 3
Activity: 44
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn