基本信息
浏览量:81
职业迁徙
个人简介
A number of age-related pathologies are associated with abnormal telomere length, suggesting that telomere defects may play a role in aging. It is believed that owing to its repetitive sequence, telomere can form unusual secondary structures (e.g., G-quadruplex and a lariat-like T-loop configuration), both of which impact telomere maintenance. We investigate the hypothesis that inadequate DNA structural resolution would impact telomere maintenance and function. Using a combination of molecular, genetic, and biochemical approaches, we are interested in probing (1) the key genes that modulate unique DNA secondary structures at telomeres; and (2) the contributions of DNA resolution deficiency to telomere defects in aging and premature aging syndromes. These studies will enhance our understanding of how DNA resolution deficiencies affect telomere maintenance and thus aging and related human diseases.
研究兴趣
论文共 60 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Allison B Herman,Dimitrios Tsitsipatis,Carlos Anerillas,Krystyna Mazan-Mamczarz, Angelica E Carr, Jordan M Gregg,Mingyi Wang,Jing Zhang,Marc Michel, Charnae' Henry-Smith, Sophia C Harris,Rachel Munk,
Amanda J. Stock, Saipriya Ayyar, Amogh Kashyap, Yunong Wang,Hagai Yanai,Matthew F. Starost,Mayuri Tanaka-Yano,Monica Bodogai,Chongkui Sun,Yajun Wang,Yi Gong,Chandrakala Puligilla,
Frontiers in aging (2021): 785171
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn