John Yates
Professor
Department of Molecular Medicine
The Scripps Research Institute;Yates Laboratory, Department of Chemical Physiology, The Scripps Research Institute;Department of Molecular and Cellular Neuroscience, The Scripps Research Institute;Skaggs Graduate School of Chemical and Biological Sciences, The Scripps Research Institute
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基本信息
views: 11
Career Trajectory
Bio
Research Focus
Genomic and EST sequencing projects are providing a sequence infrastructure that is changing how protein biochemistry is practiced. These data along with mass spectrometry provide the cornerstone technologies fueling the proteomics revolution. Our group is focused on developing tools and strategies in proteomics to answer basic biological questions. By coupling the additional amino acid sequence information that can be obtained using peptide tandem mass spectrometry to "back-end" database searching and "front-end" separative techniques, we are able to directly analyze extremely complex protein mixtures. The applications for these technologies vary from analyzing purified protein complexes to studying host-pathogen interactions in diseases such as malaria or anthrax. We are further extending these applications to find post-translational modifications to the proteins within these same complex mixtures.
Genomic and EST sequencing projects are providing a sequence infrastructure that is changing how protein biochemistry is practiced. These data along with mass spectrometry provide the cornerstone technologies fueling the proteomics revolution. Our group is focused on developing tools and strategies in proteomics to answer basic biological questions. By coupling the additional amino acid sequence information that can be obtained using peptide tandem mass spectrometry to "back-end" database searching and "front-end" separative techniques, we are able to directly analyze extremely complex protein mixtures. The applications for these technologies vary from analyzing purified protein complexes to studying host-pathogen interactions in diseases such as malaria or anthrax. We are further extending these applications to find post-translational modifications to the proteins within these same complex mixtures.
Research Interests
Papers共 1491 篇Author StatisticsCo-AuthorSimilar Experts
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Raquel de Almeida Schneider,Paula Barros Terraciano,Pamela Zanon, Letícia Quandt, Debora Helena Zanini Gotardi,Tuane Nerissa Alves Garcez,Lucélia Santi,Walter Orlando Beys da Silva,Ivan Sereno Montenegro,John Yates,Jorge Almeida Guimarães,Eduardo Pandolfi Passos,
Toxicon : official journal of the International Society on Toxinology (2024): 107630-107630
Jon M. Steichen,Ivy Phung, Eugenia Salcedo,Gabriel Ozorowski,Jordan R. Willis,Sabyasachi Baboo,Alessia Liguori,Christopher A. Cottrell,Jonathan L. Torres, Patrick J. Madden, Krystal M. Ma,Henry J. Sutton,
Scienceno. 6697 (2024): eadj8321-eadj8321
NATURE IMMUNOLOGYno. 6 (2024): 1073-1082
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAno. 5 (2024)
JOURNAL OF PROTEOME RESEARCHno. 3 (2024): 1129-1129
biorxiv(2024)
Yi Xie, Ruoxi Wang,Daniel B McClatchy,Yuanhui Ma,Jolene Diedrich, Manuel Sanchez-Alavez,Michael Petrascheck,John R Yates,Hollis T Cline
bioRxiv : the preprint server for biology (2024)
Science translational medicineno. 748 (2024): eadn0223-eadn0223
Science (New York, N.Y.)no. 6697 (2024): eadk0582-eadk0582
Nature immunologyno. 7 (2024): 1307-1307
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Author Statistics
#Papers: 1495
#Citation: 168591
H-Index: 194
G-Index: 370
Sociability: 9
Diversity: 0
Activity: 5
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