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Differentiation of hemtopoietic cells is described as a sequential process of cell fate decision originating from hematopoietic stem cells (HSC). HSCs reside in specialized microenvironments of the bone marrow called 'niche's, and signals mediated by the niches maintain the HSCs in the immature state. HSCs are recruited into the cell cycle by the niche signals under the myelosuppressive state, and the subsequent differentiation processes are regulated by various hematopoietic-specific transcription factors, such as C/EBPα and PU.1. These transcription factors dictate lineage specification at various stages of differentiation. The process of differentiation is considered to be irreversible and it has been believed that mature hematopoietic cells do not change their phenotype after they have once differentiated. However, we have shown that even mature hematopoietic cells retain plasticity and can be reprogrammed into other lineages by provision of the appropriate stimuli.
We are currently attempting to elucidate the molecular mechanisms underlying HSC physiology and hematopoiesis, and to apply the knowledge gained to artificially regulate the differentiation of hematopoietic cells. Our goal is to 1) generate reprogrammed multipotent progenitors from mature hematopoietic cells, 2) induce ex-vivo expansion of HSCs, both of which would be extremely useful for regenerative medicine and cellular therapies in the future.
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Papers共 548 篇Author StatisticsCo-AuthorSimilar Experts
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crossref(2023)
Japanese Journal of Lung Cancerno. 4 (2023): 319-324
crossref(2023)
Blood Advancesno. 19 (2021): 3830-3838
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#Papers: 549
#Citation: 24087
H-Index: 69
G-Index: 138
Sociability: 8
Diversity: 1
Activity: 0
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