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Gene regulation in tissue regeneration and tumorigenesis
The proper gene expression program is regulated at the transcription level through the interplay among epigenetic, trans- (e.g. transcription factor, chromatin modifier) and cis-regulatory (e.g. promoter, enhancer) elements, and disruption of transcriptional regulatory network causes human diseases, such as degenerative disorder and cancer. We are a functional genomics lab focusing on the fundamental gene regulation mechanism that control tissue repair and cancer development. Our lab use muscle stem cell, rhabdomyosarcoma (a life-threatening pediatric sarcoma), and glioblastoma as model system, and work at the intersection of functional genomics, cell biology and bioengineering, to employ integrative approaches including (but not limited to) epigenome and 3D-genome analysis, high-throughput genome and epigenome editing, single-cell genomics, animal model, human stem cell and organoid system, for understanding and treating complex disorders related to tissue regeneration, aging, and cancer.
The proper gene expression program is regulated at the transcription level through the interplay among epigenetic, trans- (e.g. transcription factor, chromatin modifier) and cis-regulatory (e.g. promoter, enhancer) elements, and disruption of transcriptional regulatory network causes human diseases, such as degenerative disorder and cancer. We are a functional genomics lab focusing on the fundamental gene regulation mechanism that control tissue repair and cancer development. Our lab use muscle stem cell, rhabdomyosarcoma (a life-threatening pediatric sarcoma), and glioblastoma as model system, and work at the intersection of functional genomics, cell biology and bioengineering, to employ integrative approaches including (but not limited to) epigenome and 3D-genome analysis, high-throughput genome and epigenome editing, single-cell genomics, animal model, human stem cell and organoid system, for understanding and treating complex disorders related to tissue regeneration, aging, and cancer.
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论文共 68 篇作者统计合作学者相似作者
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Kazunori Ando,Jianhong Ou,John D. Thompson, John Welsby, Sushant Bangru, Jingwen Shen,Xiaolin Wei,Yarui Diao,Kenneth D. Poss
DEVELOPMENTAL CELLno. 5 (2024): 676-691.e5
Ga I Ban,Vijitha Puviindran, Yu Xiang, Puvi Nadesan,Jackie Tang,Jianhong Ou,Nicholas Guardino,Makoto Nakagawa, MaKenna Browne, Asjah Wallace,Koji Ishikawa,Eijiro Shimada,
iScienceno. 7 (2024): 110187-110187
Vijitha Puviindran,Eijiro Shimada, Zeyu Huang,Xinyi Ma,Ga I Ban,Yu Xiang, Hongyuan Zhang,Jianhong Ou,Xiaolin Wei,Makoto Nakagawa,John Martin,Yarui Diao,
Research square (2024)
Qunsheng Dai, Changxin Wan, Yueyuan Xu, Kaileen Fei,Lindsey A Olivere, Brianna Garrett, Leo Akers,Derek Peters,James Otto, Christopher D Kontos, Zhiceng Ji,Yarui Diao,
bioRxiv : the preprint server for biology (2024)
Current Protocolsno. 10 (2023)
Xiaochen Wang,Qifeng He,Chuanli Zhou,Yueyuan Xu,Danhui Liu,Naoto Fujiwara,Naoto Kubota, Arielle Click, Polly Henderson,Janiece Vancil,Cesia Ammi Marquez,Ganesh Gunasekaran,
Natureno. 7987 (2023): 633-642
JVS - Vascular Science (2023): 100155-100155
bioRxiv : the preprint server for biologyno. 11S (2023): 817-817
Min Jin Lee,Manel Ben Hammouda, Wanying Miao, Arinze Okafor,Yingai Jin,Huiying Sun, Vaibhav Jain, Vadim Markovtsov,Yarui Diao, Simon G Gregory,Jennifer Y Zhang
bioRxiv : the preprint server for biology (2023)
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