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With the discovery of the first histone methyl eraser, LSD1, in 2004, our group demonstrated that histone methylation is dynamically regulated, which overturned the long-held dogma that such modifications were static and irreversible. We have also discovered many additional histone demethylases with different specificities, and novel readers, including those that specifically recognise unmodified lysine and arginine and suggest that the unmodified states are not simply a ground neutral state of epigenetic information but rather likely code for epigenetic information as modified states.
We are also studying RNA modifications and how they impact gene expression regulation. In many ways this exciting field parallels the early days of chromatin biochemistry and biology, i.e., the nature and the biological and pathological functions of RNA modifications, as well as the enzymes responsible for writing, erasing and reading them, are just beginning to be understood.
At Ludwig Oxford, my lab is focusing on two cancers – acute myeloid leukaemia and diffuse intrinsic pontine glioma - where chromatin/epigenetics have been shown to play a crucial role in the maintenance of a poorly differentiated state. We are exploring combinatorial mechanisms that promote cancer cell differentiation and therefore may provide the rationale needed for therapeutic considerations. We are also exploring epigenetic regulators in cancer and the host immune system to find ways to turn “cold’ tumours “hot” and to help ensure sustained response to tumour immune checkpoint blockade therapy.
We are also studying RNA modifications and how they impact gene expression regulation. In many ways this exciting field parallels the early days of chromatin biochemistry and biology, i.e., the nature and the biological and pathological functions of RNA modifications, as well as the enzymes responsible for writing, erasing and reading them, are just beginning to be understood.
At Ludwig Oxford, my lab is focusing on two cancers – acute myeloid leukaemia and diffuse intrinsic pontine glioma - where chromatin/epigenetics have been shown to play a crucial role in the maintenance of a poorly differentiated state. We are exploring combinatorial mechanisms that promote cancer cell differentiation and therefore may provide the rationale needed for therapeutic considerations. We are also exploring epigenetic regulators in cancer and the host immune system to find ways to turn “cold’ tumours “hot” and to help ensure sustained response to tumour immune checkpoint blockade therapy.
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biorxiv(2024)
MECHANICS OF ADVANCED MATERIALS AND STRUCTURESno. 4 (2024): 805-819
Violetta Karwacki-Neisius,Ahram Jang,Engin Cukuroglu,Albert Tai,Alan Jiao,Danilo Predes, Joon Yoon,Emily Brookes,Jiekai Chen, Aimee Iberg,Florian Halbritter,Katrin Õunap,
Natureno. 8004 (2024): 594-603
IEEE GEOSCIENCE AND REMOTE SENSING LETTERS (2024): 1-5
Neuro-Oncologyno. Supplement_1 (2023): i16-i17
Composites Part B: Engineering (2023): 110973-110973
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Mandi Mu,Xinze Li,Li Dong,Jin Wang,Qingqing Cai,Yajun Hu, Duanduan Wang,Peng Zhao,Lei Zhang, Daixuan Zhang,Siyi Cheng,Li Tan,
Cell reportsno. 6 (2023): 112650-113116
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