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Bio
Dr. Decheng Yang’s research programs focus on molecular pathogenesis of coxsackievirus-induced myocarditis and dilated cardiomyopathy. The ongoing research projects include: 1) molecular mechanism of coxsackievirus replication, specifically focusing on the identification of cellular 5’TOP (Terminal oligopyrimidine tract) mRNAs in the regulation of viral transcription and translation. 2) Epigenetic analysis of N6-methyladenosine (m6A) methylation of viral and cellular mRNAs. This project aims to determine the effect of RNA m6A methylation on viral propagation and pathogenesis, and 3) Host gene response to viral infection: by using an inducible heart-specific NFAT5 (nuclear factor of activated T cells 5) knockout mice as a model system, Dr. Yang’s group focuses on study of host-viral interaction, particularly on the roles of NFAT5 and viral proteases in the pathogenesis of virus-induced heart diseases. These studies aim to identify key genes involved in host immune response signaling pathways leading to cardiomyocyte injury and heart dysfunction. The identified novel genes may serve as potential targets to design nucleic acid-based therapeutics (siRNA, antisense oligo and artificial microRNA) for the treatment of the disease.
Research Interests
Papers共 130 篇Author StatisticsCo-AuthorSimilar Experts
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Guangze Zhao,Huifang M. Zhang, Ali Reza Nasseri,Fione Yip,Nikita Telkar, Yankuan T. Chen, Sana Aghakeshmiri, Christoph Küper,Wan Lam,Wenli Yang, James Zhao,Honglin Luo,
Basic Research in Cardiologypp.1-18, (2024)
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2023): 1151069
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCESno. 9 (2023): 7717-7717
wf(2022)
Ming Wang,Zhenzhao Sun,Chenxi Cui,Shida Wang,Decheng Yang,Zhibin Shi,Xinyu Wei,Pengfei Wang,Weiyao Sun,Jing Zhu, Jiaqi Li, Bingchen Du,
Shuxuan Li,Najealicka Armstrong, Huan Zhao, Ruth Cruz-Cosme,Hongwei Yang,Chunlian Zhong,Wenkun Fu, Wei Wang,Decheng Yang, Ningshao Xia, Tong Cheng, Qiyi Tang
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Author Statistics
#Papers: 130
#Citation: 3893
H-Index: 33
G-Index: 58
Sociability: 6
Diversity: 1
Activity: 0
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