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Description of Research Expertise
Research Interests: Genetic and epigenetic mechanisms controlling the development and evolution of skin appendage traits.
Keywords: sweat gland, hair follicle, mammary gland, evolution, enhancer biology, mouse genetics
Research Details: The primary research foucs of the Kamberov lab is to define the developmental pathways and regulatory elements that control the specification and patterning of sweat glands, hair follicles and mammary glands and to discover how these components have been modified during evolution to generate diversity in skin traits among modern humans as well as to give rise to some of the most singular phenotypes that define the human species, including the loss of fur and massively increased sweat gland density of humans. To this end, the lab leverages powerful genetic and genome editing tools for discovery and functional testing in the mouse coupled with in vitro study in mouse and human cell culture, as well as high-through put screening in virally-mediated transgenic mice and single nucleus transcriptomics.
Rotation projects:
Computational analysis of single transcriptomic data to define a differential transcriptional blue-print for fate specification in the skin.
Comparative analysis of skin appendage phenotypes of humanized mice expressing positively selected human genetic variants.
Research Interests: Genetic and epigenetic mechanisms controlling the development and evolution of skin appendage traits.
Keywords: sweat gland, hair follicle, mammary gland, evolution, enhancer biology, mouse genetics
Research Details: The primary research foucs of the Kamberov lab is to define the developmental pathways and regulatory elements that control the specification and patterning of sweat glands, hair follicles and mammary glands and to discover how these components have been modified during evolution to generate diversity in skin traits among modern humans as well as to give rise to some of the most singular phenotypes that define the human species, including the loss of fur and massively increased sweat gland density of humans. To this end, the lab leverages powerful genetic and genome editing tools for discovery and functional testing in the mouse coupled with in vitro study in mouse and human cell culture, as well as high-through put screening in virally-mediated transgenic mice and single nucleus transcriptomics.
Rotation projects:
Computational analysis of single transcriptomic data to define a differential transcriptional blue-print for fate specification in the skin.
Comparative analysis of skin appendage phenotypes of humanized mice expressing positively selected human genetic variants.
Research Interests
Papers共 22 篇Author StatisticsCo-AuthorSimilar Experts
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Heather L. Dingwall,Reiko R. Tomizawa,Adam Aharoni,Peng Hu,Qi Qiu,Blerina Kokalari, Serenity M. Martinez,Joan C. Donahue,Daniel Aldea, Meryl Mendoza,Ian A. Glass, Birth Defects Research Laboratory (BDRL),
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Heather L Dingwall,Reiko R Tomizawa,Adam Aharoni,Peng Hu,Qi Qiu,Blerina Kokalari, Serenity M Martinez,Joan C Donahue,Daniel Aldea, Meryl Mendoza,Ian A Glass,Hao Wu,
Developmental cellno. 1 (2023): 20-32.e6
Journal of Investigative Dermatologyno. 8 (2022): B32-B32
Journal of Investigative Dermatology (2022)
PLOS Geneticsno. 2 (2022): e1010614-e1010614
biorxiv(2020)
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