基本信息
浏览量:3
职业迁徙
个人简介
Research Interests
The main emphasis of my research is focused on deciphering the signal transduction pathways of drug resistance and apoptosis as it pertains to in cancer biology. Using novel TCM (Traditional Chinese Medicine) herbal extracts and established chemotherapeutic agents, my laboratory is currently working on the signal transduction pathways that are crucial in inducing apoptosis in cancer cells. The role of histone deacetylase, prenylation, methylation and acetylation inhibitors are currently being investigated as therapeutic agents for the treatment of a variety of cancers. In addition, putative proto-oncogenic transcription factors, like those of Kruppel-like family of transcription factors are being investigated for their role in tumorgenesis. In trying to decipher cancer signal transduction pathways, my lab is currently in the process of establishing a first order transcriptional network for these transcription factors. In conjunction with expression profile analysis, we also make use of shRNA libraries, HTS (high-throughput screening) and global transcription factor binding site analysis to answer some of the basic biology underlying drug resistance and apoptosis.
The main emphasis of my research is focused on deciphering the signal transduction pathways of drug resistance and apoptosis as it pertains to in cancer biology. Using novel TCM (Traditional Chinese Medicine) herbal extracts and established chemotherapeutic agents, my laboratory is currently working on the signal transduction pathways that are crucial in inducing apoptosis in cancer cells. The role of histone deacetylase, prenylation, methylation and acetylation inhibitors are currently being investigated as therapeutic agents for the treatment of a variety of cancers. In addition, putative proto-oncogenic transcription factors, like those of Kruppel-like family of transcription factors are being investigated for their role in tumorgenesis. In trying to decipher cancer signal transduction pathways, my lab is currently in the process of establishing a first order transcriptional network for these transcription factors. In conjunction with expression profile analysis, we also make use of shRNA libraries, HTS (high-throughput screening) and global transcription factor binding site analysis to answer some of the basic biology underlying drug resistance and apoptosis.
研究兴趣
论文共 34 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Advances in Integrative Medicine (2024)
Chester Yan Jie Ng,Yan Zhao,Ning Wang, Kwan Leung Chia, Chun Huat Teo, William Peh, Pansy Yeo,Linda L. D. Zhong
CHINESE MEDICINEno. 1 (2024): 44-44
Chester Yan Jie Ng,Yan Zhao,Ning Wang, Kwan Leung Chia, Chun Huat Teo, William Peh, Pansy Yeo,Linda L. D. Zhong
Scientific reportsno. 1 (2023): 19932-12
JOURNAL OF MEDICAL VIROLOGYno. 8 (2023): e29051-e29051
Frontiers in immunology (2023): 1234307
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn