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CRISPR-Cas is a RNA-guided, genetic interference pathway in prokaryotes that enables acquired immunity against invasive nucleic acids. Nowadays, CRISPRs also provide formidable tools for facile, programmable genome engineering in eukaryotes. Cas9 proteins are the “effector” endonucleases for CRISPR interference; and have recently begun to be also recognized as important players in other aspects of bacterial physiology (e.g., acquisition of new spacers into CRISPRs, endogenous gene regulation, microbial pathogenesis). My laboratory is broadly interested in CRISPR biology and mechanism. We use Neisseria species as our model system, and E. coli and human cells as additional platforms. We employ complementary biochemical, microbiological, genetic and genomic approaches. We are also interested in working with the broader scientific community to develop and apply novel CRISPR-based tools to tackle diverse biological questions.
CRISPR-Cas is a RNA-guided, genetic interference pathway in prokaryotes that enables acquired immunity against invasive nucleic acids. Nowadays, CRISPRs also provide formidable tools for facile, programmable genome engineering in eukaryotes. Cas9 proteins are the “effector” endonucleases for CRISPR interference; and have recently begun to be also recognized as important players in other aspects of bacterial physiology (e.g., acquisition of new spacers into CRISPRs, endogenous gene regulation, microbial pathogenesis). My laboratory is broadly interested in CRISPR biology and mechanism. We use Neisseria species as our model system, and E. coli and human cells as additional platforms. We employ complementary biochemical, microbiological, genetic and genomic approaches. We are also interested in working with the broader scientific community to develop and apply novel CRISPR-based tools to tackle diverse biological questions.
Research Interests
Papers共 29 篇Author StatisticsCo-AuthorSimilar Experts
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Qiqing Shen,Haihua Ruan,Hongyang Zhang,Tao Wu, Kexin Zhu,Wenying Han, Rui Dong, Tianwei Ming, Haikun Qi,Yan Zhang
FRONTIERS IN MICROBIOLOGY (2024): 1375120-1375120
MBIOno. 2 (2024): e0302523-e0302523
MOLECULAR CELLno. 3 (2024): 463-475.e5
Current protocolsno. 2 (2022): e361-e361
The CRISPR Journalno. SP3 (2020): 140-142
Molecular cellno. 5 (2019): 936-950.e5
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