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The main emphasis of my research is focused on deciphering the signal transduction pathways of drug resistance and apoptosis as it pertains to in cancer biology. Using novel TCM (Traditional Chinese Medicine) herbal extracts and established chemotherapeutic agents, my laboratory is currently working on the signal transduction pathways that are crucial in inducing apoptosis in cancer cells. The role of histone deacetylase, prenylation, methylation and acetylation inhibitors are currently being investigated as therapeutic agents for the treatment of a variety of cancers. In addition, putative proto-oncogenic transcription factors, like those of Kruppel-like family of transcription factors are being investigated for their role in tumorgenesis. In trying to decipher cancer signal transduction pathways, my lab is currently in the process of establishing a first order transcriptional network for these transcription factors. In conjunction with expression profile analysis, we also make use of shRNA libraries, HTS (high-throughput screening) and global transcription factor binding site analysis to answer some of the basic biology underlying drug resistance and apoptosis.
The main emphasis of my research is focused on deciphering the signal transduction pathways of drug resistance and apoptosis as it pertains to in cancer biology. Using novel TCM (Traditional Chinese Medicine) herbal extracts and established chemotherapeutic agents, my laboratory is currently working on the signal transduction pathways that are crucial in inducing apoptosis in cancer cells. The role of histone deacetylase, prenylation, methylation and acetylation inhibitors are currently being investigated as therapeutic agents for the treatment of a variety of cancers. In addition, putative proto-oncogenic transcription factors, like those of Kruppel-like family of transcription factors are being investigated for their role in tumorgenesis. In trying to decipher cancer signal transduction pathways, my lab is currently in the process of establishing a first order transcriptional network for these transcription factors. In conjunction with expression profile analysis, we also make use of shRNA libraries, HTS (high-throughput screening) and global transcription factor binding site analysis to answer some of the basic biology underlying drug resistance and apoptosis.
Research Interests
Papers共 81 篇Author StatisticsCo-AuthorSimilar Experts
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Advances in Integrative Medicine (2024)
Chester Yan Jie Ng,Yan Zhao,Ning Wang, Kwan Leung Chia, Chun Huat Teo, William Peh, Pansy Yeo,Linda L. D. Zhong
CHINESE MEDICINEno. 1 (2024): 44-44
Vengatesh Ganapathy,Mayilvanan Chinnaiyan, Daniel Brobst,Balaji Sadhasivam, Jean D. Nshimiyimana,Yan Zhao,Theodore Wagener,Lurdes Queimado
CANCER RESEARCHno. 7 (2024)
FRONTIERS IN MEDICINE (2024): 1349615-1349615
Chester Yan Jie Ng,Yan Zhao,Ning Wang, Kwan Leung Chia, Chun Huat Teo, William Peh, Pansy Yeo,Linda L. D. Zhong
Lin Wang, Skyler Quine,Alex N. Frickenstein, Michael Lee,Wen Yang,Vinit M. Sheth, Margaret D. Bourlon,Yuxin He, Shanxin Lyu,Lucila Garcia-Contreras,Yan D. Zhao,Stefan Wilhelm
ADVANCED FUNCTIONAL MATERIALSno. 8 (2023)
Scientific reportsno. 1 (2023): 19932-12
Carol Ho-Yan Fong,Xiaojuan Zhang,Lin-Lei Chen,Rosana Wing-Shan Poon,Brian Pui-Chun Chan,Yan Zhao,Carlos King-Ho Wong,Kwok-Hung Chan,Kwok-Yung Yuen, Ivan Fan-Ngai Hung,Jacqueline Kwan Yuk Yuen, Kelvin Kai-Wang To
EBioMedicine (2023): 104446
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