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Dr. Yi Li studies breast cancer initiation and metastasis. His lab pioneered an intraductal retroviral mouse model (RCAS/TVA) to closely recapitulate human breast tumorigenesis, identified a mammary progenitor cell population (cytokeratin 6+) and its contribution to breast cancer heterogeneity, discovered a molecular mechanism underlying the dichotomous effects of pregnancy on breast tumorigenesis, and established intermittent anti-STAT5 treatment for preventing breast cancer in preclinical models, which has resulted in a multi-center window-of-opportunity clinical trial (TBCRC042).
Research Interests
Papers共 168 篇Author StatisticsCo-AuthorSimilar Experts
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crossref(2024)
Cancer Researchno. 9_Supplement (2024): PO1-25
Cold Spring Harbor perspectives in medicineno. 3 (2024): a041328-a041328
Qian Zhu, Akhila Balasubramanian,Jaya Ruth Asirvatham,Badrajee Piyarathna,Jaspreet Kaur, Nada Mohamed,Ling Wu, Megha Chatterjee, Stacy Wang,Niloufar Pourfarrokh,Uttam Rasaily, Yitian Xu,
biorxiv(2024)
Wen Bu,Yi Li,Chad J. Creighton, Kelsey S. Heavener,Carolina Gutierrez,Yongchao Dou,Weiyu Jiang, Bing Zhang,Amy T. Ku,Shixia Huang
CANCER RESEARCHno. 3 (2024)
bioRxiv : the preprint server for biology (2023)
Signal Transduction and Targeted Therapyno. 1 (2023): 1-15
Nanomedicine (London, England)no. 9 (2023): 755-767
Journal of visualized experiments : JoVE (2023)
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