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个人简介
Dr. Huang is currently an Assistant Professor at the Center for Epigenetics and Disease Prevention, Institute of Biosciences & Technology, Texas A&M University. Her long-term goal is to elucidate the molecular basis of epigenetic changes in the human genome and to develop novel therapies by targeting aberrant DNA methylation and demethylation associated with human diseases, including cancer, immunoinflammatory and cardiovascular diseases.
Dr. Huang received her basic and clinical training in Zhejiang University School of Medicine. During my graduate training at Georgia State University, she mainly focused on understanding the mechanisms underlying the Ca2+-mediated regulation of the extracellular calcium sensing receptor (JBC 2007 & 2010, Biochemistry 2008, NSMB 2010, PNAS 2011). As a postdoctoral fellow in Dr. Anjana Rao’s laboratory at Harvard Medical School and later an Instructor at La Jolla Institute for Allergy and Immunology, she played a leading role in understanding the biological roles of TET enzymes and novel 5-methylcytosine modifications in hematological malignancies, and am among the first to perform genome-wide profiling of DNA hydroxymethylome in embryonic stem cells (Nature 2010 & 2011, Cell Stem Cell 2011 & 2013, Blood 2011, Nature Protocol 2012, Science 2013, PNAS 2014). Her work affords novel insights in our understanding of the function of TET protein and DNA methylation/ demethylation balance during development and malignant transformation.
Dr. Huang's laboratory is focused on elucidating the physiological and pathophysiological functions of TET2 protein and its 5-methylcytosine oxidation products (5hmC, 5fC and 5caC) in cancer and development (Nature Genet 2014; Trends in Genetics 2014).
研究兴趣
论文共 192 篇作者统计合作学者相似作者
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Guo Feng,Caiyao Han,Qian Qin,Wei Li,Youli Chen,Gang Liu,Yan Lei, Tingting Liu,Kexin Ma,Jinxin Hou,Yun Huang, Mingjin Lin,
crossref(2024)
HemaSphereno. 6 (2024): e90-e90
Yaling Dou, Yan Zhang, Logan Rivera,Tingting Hong,Shaohai Fang, Thuy Tien Tran,Yubin Zhou,James F. Martin,Yun Huang
CLINICAL AND TRANSLATIONAL MEDICINEno. 6 (2024)
Yuhan Yang, Maryn Cavalier, Ashley Suris, Kevin Chen, Claire An, Jingyuan Fan, Logan Rivera,Shaohai Fang,Lei Guo,Yubin Zhou,Yun Huang
Frontiers in Epigenetics and Epigenomics (2024)
Yandong Zhou,Michelle R. Jennette,Guolin Ma,Sarah A. Kazzaz,James H. Baraniak,Robert M. Nwokonko, Mallary L. Groff, Marcela Velasquez-Reynel,Yun Huang,Youjun Wang,Donald L. Gill
Nature communicationsno. 1 (2023)
Tingting Hong,Jia Li,Lei Guo, Maryn Cavalier,Tianlu Wang,Yaling Dou, Aaron DeLaFuente,Shaohai Fang,Anna Guzman, Katherina Wohlan,Chiraag Kapadia,Carina Rosas,
Nature agingno. 11 (2023): 1387-1400
Elsevier eBooks (2023)
European journal of gastroenterology & hepatologyno. 8 (2023): 854-864
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作者统计
#Papers: 196
#Citation: 13414
H-Index: 48
G-Index: 115
Sociability: 7
Diversity: 4
Activity: 185
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