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个人简介
My research foci are mechano-transduction mechanisms by which cells sense and convert environmental mechanical stimuli into biological signaling and novel nanomedicine approaches that target dysregulated mechano-sensing pathways. Cellular mechanotransduction is instrumental to embryogenesis and physiological control of tissue homeostasis; abnormal cell responses to mechanical forces promote pathologies associated with numerous human diseases. This is especially important in the vasculature, where environmental mechanical stimuli produce cellular responses in endothelial cells at arterial curvatures and bifurcations by locally disturbed blood flow to induce atherosclerosis. A similar cascade appears to be induced in acute lung injury where it is the increased cyclic stretch that is the trigger. My research program at the University of Chicago focuses on the molecular understanding of endothelial homeostasis governed by mechanical forces, with emphasis upon regulation of non-coding genome, transcription factors, G protein signaling, and genetic variance. Another major research goal is to develop innovative nanomedicine-based therapeutic strategies to treat dysregulated mechano-sensing mechanisms causing vascular diseases. Key Words: microRNA, non-coding RNA, human genetics, enhancer biology, vascular biology, nanotechnology, nanomedicine, mechanotransduction, atherosclerosis, acute lung injury
研究兴趣
论文共 113 篇作者统计合作学者相似作者
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Ilakya Selvarajan,Miika Kiema,Ru-Ting Huang,Jin Li,Jiayu Zhu,Petri Pölönen,Tiit Örd,Kadri Õunap,Mehvash Godiwala, Anna Kathryn Golebiewski,Aarthi Ravindran,Kiira Mäklin,
Arteriosclerosis, thrombosis, and vascular biologyno. 6 (2024): 1330-1345
Shailaja Seetharaman,John Devany, Ha Ram Kim, Emma van Bodegraven, Theresa Chmiel,Shentu Tzu-Pin,Wen-Hung Chou,Yun Fang,Margaret Lise Gardel
bioRxiv : the preprint server for biology (2024)
Lisa R. Volpatti, Salvador Norton de Matos, Gustavo Borjas,Joseph Reda,Elyse A. Watkins,Zhengjie Zhou,Mindy Nguyen,Ani Solanki,Yun Fang,Jeffrey A. Hubbell
bioRxiv the preprint server for biology (2024)
bioRxiv : the preprint server for biology (2024)
Yuechun Zhu, Yu Feng, Qinxuan Ni, Na Wu, Taiyu Xie,Fang Yun,Xuedan Zhang, Lingnan Gao, Yanlong Gai, Enjiang Li,Xiaojia Yi, Junlin Xie,
crossref(2024)
Journal of Immunologyno. 1 (2023): 249.08-249.08
Molecular systems biologyno. 12 (2023): e11462-e11462
American journal of physiology. Lung cellular and molecular physiologyno. 1 (2023): L111-L123
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