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The research in our laboratory is focused on cell therapy to regenerate the damaged myocardium and restore cardiac function following a myocardial infarction. We use a combination of gene profiling, tissue engineering, physiological testing, and molecular imaging techniques to investigate whether the cardiac regenerative capacity of stem cells is associated with their survival, proliferation, and/or differentiation. We have obtained substantial expertise in this field, and have published our findings in peer-reviewed journals, including JACC, JMCC, Circulation, Cir Res, Stem Cell, Stem Cells and Development, AJP, and etc. We have engineered bone marrow derived mesenchymal stem cells (MSCs) carrying different genes, e.g., Wnt11, GATA-4, etc. to increase the capacity of stem cells to regenerate ischemic myocardium.
MSC preprogrammed to overexpress GATA-4 (MSCGATA-4) can significantly accelerate repair of ischemic heart tissue. We have demonstrated that paracrine effect plays a critical role in MSCGATA-4 mediated cardiac regeneration. Extracellular vesicles (EVs), including microvesicles (MVs) and exosomes (EXO), have been identified as the paracrine factors secreted by MSCs. One of our present research programs is to characterize EVs that are secreted from MSCGATA-4, and to elucidate the molecular processes of their biogenesis and uptake. We will also investigate the molecular basis for their efficacy in reducing tissue injury in animal models of myocardial ischemia, stroke and other diseases. This research will provide the platform from which to translate our research findings into clinical applications.
The research in our laboratory is focused on cell therapy to regenerate the damaged myocardium and restore cardiac function following a myocardial infarction. We use a combination of gene profiling, tissue engineering, physiological testing, and molecular imaging techniques to investigate whether the cardiac regenerative capacity of stem cells is associated with their survival, proliferation, and/or differentiation. We have obtained substantial expertise in this field, and have published our findings in peer-reviewed journals, including JACC, JMCC, Circulation, Cir Res, Stem Cell, Stem Cells and Development, AJP, and etc. We have engineered bone marrow derived mesenchymal stem cells (MSCs) carrying different genes, e.g., Wnt11, GATA-4, etc. to increase the capacity of stem cells to regenerate ischemic myocardium.
MSC preprogrammed to overexpress GATA-4 (MSCGATA-4) can significantly accelerate repair of ischemic heart tissue. We have demonstrated that paracrine effect plays a critical role in MSCGATA-4 mediated cardiac regeneration. Extracellular vesicles (EVs), including microvesicles (MVs) and exosomes (EXO), have been identified as the paracrine factors secreted by MSCs. One of our present research programs is to characterize EVs that are secreted from MSCGATA-4, and to elucidate the molecular processes of their biogenesis and uptake. We will also investigate the molecular basis for their efficacy in reducing tissue injury in animal models of myocardial ischemia, stroke and other diseases. This research will provide the platform from which to translate our research findings into clinical applications.
研究兴趣
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Stem Cell Reviews and Reportspp.1-18, (2024)
Xingyu He,Suchandrima Dutta,Jialiang Liang,Christian Paul,Wei Huang,Meifeng Xu, Vivian Chang, Ian Ao,Yigang Wang
Canadian journal of physiology and pharmacologyno. 1 (2023): 1-13
bioRxiv the preprint server for biology (2023)
Current Drug Targetsno. 13 (2023): 1055-1065
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