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Research in the Xiao lab aims to better understand transcriptome complexity in health and disease. A major surprise resulted from the Human Genome Project was that humans, even though as an apparently much complex organism with 100 trillion cells, have only 25,000 to 30,000 genes. In contrast, the roundworm, an organism with 960 cells, has ~19,000 genes. The number of genes does not scale proportionally with biological sophistication. Instead, the transcriptome (the collection of RNA molecules expressed from genes) in higher organisms is closely regulated such that one gene may produce different transcript isoforms in a cell type and developmental stage-specific manner. The Xiao lab studies transcriptome complexity focusing on RNA splicing, RNA modification and other post-transcriptional mechanisms. With both a computational (dry) lab and an experimental (wet) lab, they develop new bioinformatic methods and experimental systems to understand the regulation and function of transcriptome complexity, and apply these methods to neuropsychiatric disorders and cancer. The lab makes extensive use of second and third generation sequencing technologies in bulk tissues and single cells to drive methodology developments and biological discoveries.
Research in the Xiao lab aims to better understand transcriptome complexity in health and disease. A major surprise resulted from the Human Genome Project was that humans, even though as an apparently much complex organism with 100 trillion cells, have only 25,000 to 30,000 genes. In contrast, the roundworm, an organism with 960 cells, has ~19,000 genes. The number of genes does not scale proportionally with biological sophistication. Instead, the transcriptome (the collection of RNA molecules expressed from genes) in higher organisms is closely regulated such that one gene may produce different transcript isoforms in a cell type and developmental stage-specific manner. The Xiao lab studies transcriptome complexity focusing on RNA splicing, RNA modification and other post-transcriptional mechanisms. With both a computational (dry) lab and an experimental (wet) lab, they develop new bioinformatic methods and experimental systems to understand the regulation and function of transcriptome complexity, and apply these methods to neuropsychiatric disorders and cancer. The lab makes extensive use of second and third generation sequencing technologies in bulk tissues and single cells to drive methodology developments and biological discoveries.
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biorxiv(2023)
bioRxiv : the preprint server for biology (2023)
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iScienceno. 8 (2022): 104836-104836
bioRxiv (Cold Spring Harbor Laboratory)no. 35 (2022)
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