My major research field is epidemiology of neurodegenerative diseases in the elderly and of cardiovascular disease in middle age. My specific research interests are: (1) influence of lifestyle (smoking, vitamin B12 and folate, social network, and leisure activities) and psychosocial factors (personality, work stress, life-course cognitive reserve enhancing factors) and their interactions with genetic factors on risk of dementia, cognitive decline, metabolic health, depression and mortality; and (2) impact of psychosocial factors (social support, work stress, and depressive symptoms) on progression of coronary heart disease.