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个人简介
Expertise and interests include:
REGULATION OF STEM CELL FUNCTION AND AGING BY HEPARAN SULFATE AND SULFS:
Environmental signals play crucial roles in self-renewal of stem cells, tissue regeneration and aging. Ai lab investigates heparan sulfate-dependent mechanisms that regulate extracellular signaling during stem cell maintenance and regeneration of the skeletal muscle. Our study is focused on two heparan sulfate-modifying enzymes called Sulfs.
NEUROGENESIS AND NEUROPLASTICITY IN PULMONARY DISEASES:
The respiratory tract is known to be innervated by two groups of neurons. The intrinsic neurons have cell bodies located within the tissue, while the extrinsic neurons have their cell bodies located in the central and peripheral nervous system and their axons innervating airway smooth muscle and neuroendocrine cells. Ai lab investigates neurotrophic signals that regulate neurogenesis in developing lung and neuroplasticity in pulmonary diseases. Our goal is to understand physiological roles of neural innervation in respiratory function, diseases and regeneration.
AIRWAY SMOOTH MUSCLE DEVELOPMENT AND REMODELING IN ASTHMA:
Airway smooth muscle hyperplasia and hyper-reactivity are key features of asthma. Ai lab, in collaboration with Dr. Alan Fine’s lab, investigates mechanisms underlying the formation and remodeling of airway smooth muscle. We are particularly interested in the sonic hedgehog pathway in control of airway smooth muscle development.
研究兴趣
论文共 79 篇作者统计合作学者相似作者
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Kamakshi Bankoti,Wei Wang,Gaurang M. Amonkar, Linjie Xiong,Jessica E. Shui,Caiqi Zhao, Eric Van,Chimwemwe Mwase,Jin-Ah Park,Hongmei Mou,Yinshan Fang,Jianwen Que,
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGYno. 1 (2024): 26-38
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2023)
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American journal of human geneticsno. 10 (2023): 1787-1803
bioRxiv : the preprint server for biology (2023)
Florentine Dylong,Jan Riedel,Gaurang M. Amonkar,Nicole Peukert, Paula Lieckfeldt,Katinka Sturm,Benedikt Hoexter,Wai Hei Tse,Yuichiro Miyake, Maria Moormann,Lena Marie Bode,Steffi Mayer,
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGYno. 5 (2023): 545-555
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