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职业迁徙
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Research Interest
Molecular mechanisms of STAT3 in regulation of tumorigensis, metastasis and angiogenesis
The key functions of STAT proteins in epigenetic regulation of stem cells, development and diseases
Reprogramming mechanisms during early development and generation of adult stem cells
Mechanisms of neural development, gene circuitry for formation of cognition and related diseases
In particular, we are pursuing the following projects:
1) To investigate the critical roles of endothelial STAT3 in tumour angiogenesis. We have created an endothelial cell (EC)-specific deletion in STAT3 (STAT3E–/– for ECs) to study the pathophysiological functions of EC-expressed STAT3 in vivo. Possible epigenetic alterations induced by STAT3 activity will be examined.
2) To reveal the molecular mechanisms of tumour metastasis and the role of STAT3 during this process. Tumour metastasis involves invasion; tumour cell dissemination through blood vessels or the lymphatic system; colonization of distant organs; and, finally, the outgrowth of metastases. We are investigating the possible molecular bases responsible for this STAT3 mediated metastasis.
3) A novel direction of the lab is to investigate whether tumourigenesis can be affected via inflammation regulated by STAT3. We are investigating a hypothesis that STAT3, as an oncogene, can regulate epigenetic factors during T helper cell-mediated inflammation and cause tumourigenesis. We plan to systematically investigate the manner in which inflammatory responses cause epigenetic alterations and to study their effects on cancer development.
Molecular mechanisms of STAT3 in regulation of tumorigensis, metastasis and angiogenesis
The key functions of STAT proteins in epigenetic regulation of stem cells, development and diseases
Reprogramming mechanisms during early development and generation of adult stem cells
Mechanisms of neural development, gene circuitry for formation of cognition and related diseases
In particular, we are pursuing the following projects:
1) To investigate the critical roles of endothelial STAT3 in tumour angiogenesis. We have created an endothelial cell (EC)-specific deletion in STAT3 (STAT3E–/– for ECs) to study the pathophysiological functions of EC-expressed STAT3 in vivo. Possible epigenetic alterations induced by STAT3 activity will be examined.
2) To reveal the molecular mechanisms of tumour metastasis and the role of STAT3 during this process. Tumour metastasis involves invasion; tumour cell dissemination through blood vessels or the lymphatic system; colonization of distant organs; and, finally, the outgrowth of metastases. We are investigating the possible molecular bases responsible for this STAT3 mediated metastasis.
3) A novel direction of the lab is to investigate whether tumourigenesis can be affected via inflammation regulated by STAT3. We are investigating a hypothesis that STAT3, as an oncogene, can regulate epigenetic factors during T helper cell-mediated inflammation and cause tumourigenesis. We plan to systematically investigate the manner in which inflammatory responses cause epigenetic alterations and to study their effects on cancer development.
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Yan Zhang,Lin Zhou,Youling Gong,Meijuan Huang,Min Tang,Yongmei Liu, Min Yu,Weigang Xiu, Xinjun Liang, Xinyu Liu,Xin-Yuan Fu,You Lu
JOURNAL OF CLINICAL ONCOLOGYno. 16 (2023)
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Biochemical pharmacology (2023): 115957-115957
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