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个人简介
The main goal of our research is to identify molecular mechanisms that control cellular plasticity and suppress tumour growth. Cells are able to change their characteristics and cell fate in response to external signals. This ability to change – cellular plasticity – underlies cancer initiation, metastasis and resistance to therapy. We are particularly interested in ‘guardians’ of plasticity in epithelial cells, from which over 80% of human tumours originate. We have a long-standing interest in the tumour suppressor p53 and the ASPP family of proteins (Apoptosis-Stimulating Protein of p53; Ankyrin repeats, SH3 domain and Proline rich sequence containing proteins), which have several roles including regulation of p53.
研究兴趣
论文共 285 篇作者统计合作学者相似作者
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Haiqi Xu, Linzhen Kong,Jingfei Cheng,Khatoun Al Moussawi,Xiufei Chen, Aleema Iqbal,Peter A. C. Wing,James M. Harris,Senko Tsukuda, Azman Embarc-Buh,Guifeng Wei,Alfredo Castello,
biorxiv(2024)
Biomaterials (2024): 122691-122691
Nature communicationsno. 1 (2024): 1-15
Hannah S. Fuchs, Sabrina A. James,Thomas M. Carroll,Phil F. Xie,Joseph A. Chadwick, Duncan Parkes,Simon R. Lord,Lucinda Griffiths,Tim Underwood,Ioannis Karydis,Russell T. Petty,Benjamin Schuster-Böckler,
Cancer Researchno. 7_Supplement (2024)
Xiang'an Wu, Yuxin Wang, Sen Wang,Ye Chen,Jiashu Han,Chao Wang,Meng Zhang,Xiongwei Hu,Biao Song,Xueshuai Wan,Haifeng Xu,Haitao Zhao,
JOURNAL OF CANCERno. 10 (2024): 3024-3033
Phil Xie, Masato Innoue,Paulina Siejka-Zielińska, Robert Amess,Jaeho Chang,Sam Wilding,Gareth Griffiths,Mark R. Middleton,Richard P. Owen,Chunxiao Song,Xin Lu,Benjamin Schuster-Boeckler
Cancer Researchno. 6_Supplement (2024): 2489-2489
Phil F. Xie,Jaeho Chang,Paulina Siejka-Zielinska,Masato Inoue, Magdalena Drozdz,Joseph A. Chadwick,Thomas M. Carroll,Richard P. Owen,Michael J. White,Joseph Kaplinsky, Robert Amess,Mark Middleton,
CANCER RESEARCHno. 8 (2023)
Richard Owen, Hannah Fuchs, Sabrina James,Simon Lord,Tim Underwood,Ioannis Karydis,Russell Petty,Mark Middleton,Xin Lu
BRITISH JOURNAL OF SURGERYno. Supplement_8 (2023)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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作者统计
#Papers: 287
#Citation: 20271
H-Index: 65
G-Index: 140
Sociability: 7
Diversity: 4
Activity: 240
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