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My lab’s goal is to elucidate the molecular mechanism controlling the sequential temporal transitions in medulla neuroblasts to generate different neural types, using both genetics and genomics approaches. In a genomics approach, we compare the transcriptome profiles of medulla neuroblasts as they transit through different temporal stages using the five transcription factors as markers. In parallel, we use genetic analysis to identify the molecular players and elucidate the molecular clock. The integrated approaches are also used in our investigation of how the sequential expression of transcription factors in neuroblasts generates neural diversity. Our research will shed light on the neurogenesis of a complex adult neural structure, as well as on the general mechanism of temporal patterning of neural progenitors.
Research Interests
Research Topics
Development, Genetics, Genomics, Neurobiology, Regulation of Gene Expression
Research Interests
Papers共 30 篇Author StatisticsCo-AuthorSimilar Experts
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Cold Spring Harbor protocolsno. 3 (2024): 108157-108157
Cold Spring Harbor protocolsno. 3 (2024): 108156-108156
Social Science Research Network (2022)
Nature Communicationsno. 1 (2022): 1-19
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