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Chromatin changes caused by DNA methylation and histone modifications play crucial roles in genome stability, gene regulation, genomic imprinting and transgene silencing. DNA methylation refers to addition of a methyl group to 5’-cytosine of DNA, which extensively exists from prokaryotes to eukaryotes. In plants, the methylated genomic DNA loci are frequently accompanied by the occurrence of siRNAs and noncoding RNAs, which cause de novo DNA methylation through RNA-directed DNA methylation. The histone modifications include methylation, acetylation, phosphorylation and ubiquitination, which coordinate with DNA methylation and regulate chromatin status. We will study the RNA-directed DNA methylation and histone modification mechanisms by applying genetic, molecular biological and biochemical approaches. We attempt to identify new components in the pathway and study their functions in genome stability, development and transcriptional gene silencing. These studies will help to understand the dynamic regulation of epigenomes during plant development and adaptation to environments.
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论文共 81 篇作者统计合作学者相似作者
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Rui Zhao, Wen-Ai Wu,Yi-Hua Huang,Xin-Kai Li,Jia-Qi Han,Wu Jiao,Yin-Na Su,He Zhao,Yang Zhou, Wu-Qiang Cao,Xun Zhang,Wei Wei,
The EMBO Journalno. 19 (2023)
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Si-Yao Zheng, Bin-Bin Guan,Dan-Yang Yuan,Qiang-Qiang Zhao, Weiran Ge,Lian-Mei Tan,Shan-Shan Chen,Lin Li,She Chen,Rui-Ming Xu,Xin-Jian He
Molecular plantno. 11 (2023): 1847-1865
Guo, Jing, Cai, Guang, Li, Yong-Qiang,Zhang, Yi-Xuan,Su, Yin-Na,Yuan, Dan-Yang,Zhang, Zhao-Chen,Liu, Zhen-Zhen,Cai, Xue-Wei,Guo, Jing,Li, Lin,Chen, She,
Nature Plantsno. 12 (2022): 1423-1439
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