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个人简介
XIJIN XU: M.D., Ph.D.; Professor of Department of Biology and Genetics, Laboratory of Environmental Medicine and Developmental Toxicology, and Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology in Shantou University Medical College. At 22 Xinling Road, Shantou, 515041, P.R. China. E-Mail: xuxj@stu.edu.cn
Education
• Doctor of Philosophy (Ph. D), First Military Medical University, China, 2003
• Master of Medical Sciences (M.D.), Guangxi Medical University, China. 1998
• Doctor of Medicine (B.S.), Jianghan University Medical College, China. 1983
• Post-Doctoral Training, University of Texas Medical Branch, USA. 2005-2006
• Post-Doctoral fellow, University of Texas Medical Branch, USA. 2006-2009
Research Interests
Experimental study of spinal cord repair by tissue engineering in rats- Project supported by the National Science Foundation of Guangdong province (04020247); National Science Foundation of Educational commission of Guangdong Province (0142); and National Science Foundation of Guangdong province (022275).
My research activities focus on relationship between heavy metals and children or adolescent growth and development in electronic rubbish pollution area-Project supported by the Foundation of Greenpeace International (200307); and Fort Motor Conservation and Environmental Grants; and Shih Wing Ching Foundation Limited of Hong Kong. And focus on relationship between heavy metals and children or adolescent growth and development in electronic rubbish pollution area.Guiyu is the major electronic waste recycling town in China. The primary purpose of this study was to measure the heavy metals levels in neonates or children or adolescent, and then to examine the correlation between heavy metals levels and neurobehavioral development or growth and development.
The anther focus is the study of experimental study of spinal cord repair by tissue engineering in rats. We successfully expanded rat center neural stem cells derived from reproductive rat fetal brains for more than 96 passages in vitro. The cells are grown as neurospheres in media containing basic fibroblast growth factor, epidermal growth factor and leukemia inhibitor factor. The long-term expanded the cells show normal diploid karyotype, similar growth rate and capability to differentiate into all three neural lineages (neurons, astroglia and oligodendrocytes). We developed to guide the cells to become cholinergic motor neurons for further differentiation in vitro. Many primed the cells with human keratin transplanted into contusion-injured rat spinal cords, and to observe the cells growth and move along the human keratin and differentiate to function neural cells.
Mechanisms of neurogenic inflammation on the spinal cord injury-induced central and peripheral pain sensitization-Project supported by the Science Foundation of Shantou University college (200906).
A second focus is the study of mechanisms of inhibitory effect of phenyl-N-tert-butylnitrone and 5,5-dimethylpyrroline-N-oxide on reactive oxygen species induce to central pain after spinal cord injury neurogenic inflammation on the spinal cord injury-Induced central Pain. We know that central and peripheral sensitization when spinal cord injury. SCI generates reactive oxygen species (ROS) downstream products of glutamate receptor activation and inflammatory pathways, the role of ROS in central and peripheral sensitization is unknown. SCI activates glutamate receptor-initiated biochemical pathways which in turn lead to ROS. We know that inhibition of the prostaglandin pathway (a biochemical Pathway that generates ROS), by inhibition of the COX-2 enzyme, attenuates CNP. Little else is known regarding the role of ROS in CNP. ROS generate pro-inflammatory cytokines and neurotrophins (specifically NGF and BDNF) in the spinal cord and the blood serum. The latter agents produce sensitization in peripheral neuropathic models. Generation of ROS after SCI contributes could induce to central neuropathic pain.
Professional Memberships
• Member of American Public Health Association
• Member of America Society for Neuroscience Association
• Member of Chinese Medical Association
• Member of Chinese Anatomic Association
• Member of Chinese Electron-Microscopy Association
• Member of Guangdong Human Tissue-Engineering Association
研究兴趣
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Environment Internationalpp.108622, (2024)
Ecotoxicology and Environmental Safety (2024): 116287-116287
Xueling Lu, Thomas P. van der Meer,Zoha Kamali,Martijn van Faassen,Ido P. Kema, André P. van Beek,Xijin Xu,Xia Huo,Alireza Ani,Ilja M. Nolte,Bruce H.R. Wolffenbuttel,Jana V. van Vliet-Ostaptchouk,
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Environmental research (2024): 118201-118201
ENVIRONMENT INTERNATIONAL (2024): 108396-108396
SCIENCE OF THE TOTAL ENVIRONMENT (2024): 171495-171495
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Environmental science and pollution research internationalno. 24 (2023): 64860-64871
Ecotoxicology and environmental safety (2023): 115314-115314
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