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个人简介
Xicheng Sun, Ph.D. Vice President, Chemistry & Manufacturing. Prior to his current appointment, Dr Sun was an executive director of chemistry and CFTR modulator team leader at N30 Pharmaceuticals (Nivalis Therapeutics, merged with Alpine Immune Sciences), overseeing internal and external activities from medicinal chemistry, chemical process development, and manufacturing of multi-kilo scale active pharmaceutical ingredients under cGMP, to compound screening using enzyme and cell-based assays and selection of candidate compounds for development. Prior to this appointment, he was a Principal Scientist at Replidyne, Inc. where he was responsible for discovering novel antibacterial agents against a number of biological targets, including methionyl-tRNA synthetase and bacterial DNA polymerases. Dr. Sun is an author or co-author of more than 60 scientific papers, meeting proceedings and conference presentations, and an inventor or joint-inventor of 33 issued patents, including the discovery of Telaprevir (INCIVEK), a HCV protease inhibitor approved for the treatment of HCV infection in 2011 and a number of compounds in clinical development: 1) CRS3123 (formerly REP3123), a methionyl-tRNA synthetase inhibitor completed Phase 1 clinical trials for the treatment of CDI; 2) N6022, a S-nitrosoglutathione reductase (GSNOR) inhibitor for the treatment of acute asthma and cystic fibrosis; 3) Cavosonstat (N91115), an oral S-nitrosoglutathione reductase (GSNOR) inhibitor currently in clinical trials for the treatment of COPD and asthma. Dr. Sun received his BS, MS, and Ph.D. degrees in chemistry from the Dalian University of Technology in Dalian, China and conducted his post-doctoral research at the Swiss Federal Institute of Technology (ETH) in Zürich and University of Lausanne, Switzerland.
研究兴趣
论文共 70 篇作者统计合作学者相似作者
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Swati Patel,Moti Chapagain,Clifford Mason, Matthew Gingrich,Shruti Athale,Wendy Ribble,Teresa Hoang,Joshua Day,Xicheng Sun,Thale Jarvis,Urs A. Ochsner,David Howe,
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPYno. 10 (2022): 2876-2885
James Graham, Christina E Wong,Joshua Day, Elizabeth McFaddin,Urs Ochsner,Teresa Hoang,Casey L Young,Wendy Ribble,Mary A DeGroote,Thale Jarvis,Xicheng Sun
mag(2014)
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Joan P Blonder,Sarah C Mutka,Xicheng Sun,Jian Qiu,Lucia H Green, Navdeep K Mehra, Ramakrishna Boyanapalli,Michael Suniga,Kirsten Look,Chris Delany,Jane P Richards,Doug Looker,
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