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My group has been focused on the prefrontal cortex (PFC), which is often called "the CEO of the brain". I am interested in identifying circuit properties that enable PFC to subserve higher cognitive functions, in contrast to early sensory processing. We found that a local circuit endowed with strong but slow recurrent dynamics ("reverberation") is well suited for both decision-making and working memory, suggesting a canonical "cognitive-type" neural circuit. Mathematically, such circuits are described as "attractor networks" that are characterized by powerful feedback mechanisms, long transients as well as self-sustained persistent activity. This finding led us to investigate all sorts of decision processes, including reward-based economic choice behavior, categorization, inhibitory control of action selection, attention switching, probabilistic inference. A recent collaborative work offers a theoretical explanation, supported by single-neuron data from behaving monkeys, of a common and perplexing observation that neural activities in the PFC display a high degree of mixed-selectivity and heterogeneity. Furthermore, we are keen to learn why the brain exhibits such a rich diversity of inhibitory interneuron subtypes, and their roles in tuning, normalization, competition, rhythmic synchronization. Finally, in a new field called "Computational Psychiatry" and in collaboration with psychiatrists, we use our models to examine cellular and circuit abnormalities that may be causally linked to cognitive deficits associated with mental disorders such as schizophrenia.
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bioRxiv (Cold Spring Harbor Laboratory) (2024)
Nature reviews. Neuroscience (2024)
bioRxiv : the preprint server for biology (2024)
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAno. 14 (2024): e2318521121-e2318521121
Cerebral cortex (New York, N.Y. : 1991)no. 5 (2024)
bioRxiv : the preprint server for biology (2023)
Nature Neuroscienceno. 7 (2023): 1281-1294
bioRxiv (Cold Spring Harbor Laboratory) (2023)
bioRxiv : the preprint server for biology (2023)
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