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Bio
Our research interest is using physical methods to answer fundamental biological questions at single molecule level, for example, what is the exact mechanism for a helicase to unwind duplex DNA; how polymerase works in the process of RNA transcription and DNA replication; how helicase and polymerase cooperate with each other during DNA metabolism. Currently, we are working on G-quadruplex DNA: How G-quadruplex folds and unfolds at single molecule level, the way G-quadruplex unfolds by various helicases, and the effects of G-quadruplex on the DNA, RNA polymerases. Basically, we use single fluorescence resonance energy transfer. Bulk assay including stopped-flow, fluorescence anisotropy and dynamic light scattering methods are also employed.
Research Interests
Papers共 20 篇Author StatisticsCo-AuthorSimilar Experts
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Nature Plantsno. 5 (2024): 743-748
Yang-Xue Dai,Xiao-Lei Duan,Wen-Tong Fu, Shan Wang,Na-Nv Liu,Hai-Hong Li,Xia Ai,Hai-Lei Guo, Cel Areny Naves, Elisabeth Bugnard,Daniel Auguin,Xi-Miao Hou,
JOURNAL OF MOLECULAR BIOLOGYno. 2 (2024): 168373-168373
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#Papers: 17
#Citation: 245
H-Index: 6
G-Index: 10
Sociability: 4
Diversity: 2
Activity: 26
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