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Carbohydrates play important roles in biological systems and influence cancer metastasis, bacterial and viral infection, cell-cell interactions. Carbohydrates on glycoproteins also affect their structures and functions. We focus on developing novel chemoenzymatic methods that combine the flexibility of chemical synthesis and the high efficiency and superior selectivity of enzyme-catalyzed reactions for elucidating the structure-function relationship of carbohydrates and glycoconjugates. We are also interested in structural and biochemical characterization of glycosyltransferases and other carbohydrate biosynthetic enzymes as well as designing mutants as better catalysts for carbohydrate synthesis. Additionally, developments of effective bioassays, glycosidase inhibitors, and carbohydrate-based diagnostics and therapeutics are ongoing research efforts of the group.
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Journal of Biological Chemistryno. 3 (2024)
JOURNAL OF THE AMERICAN CHEMICAL SOCIETYno. 7 (2024): 4346-4350
Cristina Di Carluccio,Linda Cerofolini, Miguel Moreira, Frederic Rosu, Luis Padilla-Cortes, Giulia Roxana Gheorghita,Zhuojia Xu,Abhishek Santra,Hai Yu, Shinji Yokoyama, Taylor E. Gray,Chris D. St. Laurent,
ACS CENTRAL SCIENCEno. 2 (2024): 447-459
Tirth Uprety,Jieshi Yu,Aitor Nogales, Ahsan Naveed,Hai Yu,Xi Chen, Yunpeng Liu,Andrew S. Bowman,Luis Martinez-Sobrido,Colin R. Parrish, Gregory B. Melikyan,Dan Wang,
ORGANIC LETTERSno. 24 (2023): 4456-4461
Valeria Conte,Franziska Luise Emmerling, Zoe Pikramenou, Lihong Jing, Kamila Kočí,Xi Chen,Elena Vladimirovna Boldyreva
Frontiers Research Topics (2023)
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Vered Padler-Karavani, Nancy Hurtado-Ziola,Minya Pu,Hai Yu,Shengshu Huang,Saddam Muthana,Harshal A. Chokhawala,Hongzhi Cao,Patrick Secrest,Dinorah Friedmann-Morvinski,Oded Singer, Darius Ghaderi,
crossref(2023)
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