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个人简介
Dr. Wong is particularly interested in understanding how pericellular proteolysis is linked to intracellular signaling in a timely and spatially controlled manner to coordinate the key cellular functions. Our studies were one of the first to point out the importance of proteolysis as a mechanism of altering intracellular signaling when most people regarded proteolysis as destructive only. We found that MT1-MMP, one of the key proteinases involved in extracellular matrix remodeling, is a critical regulator for multiple intracellular signaling pathways in diverse biological processes, including bone development (Developmental cell 2012), vessel formation (Nature Communications 2016), immune cell differentiation (EMBO J 2011) and bodyweight control (Nature Metabolism, in revision).
研究兴趣
论文共 51 篇作者统计合作学者相似作者
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BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASEno. 4 (2024): 167081-167081
Nature Communicationsno. 1 (2024): 1-14
NATURE COMMUNICATIONSno. 1 (2024)
Lixiang Zhai,Min Zhuang, Hoi Ki Wong,Chengyuan Lin,Jialing Zhang, Gengyu Bao,Yijing Zhang, Shujun Xu,Jingyuan Luo,Shuofeng Yuan,Hoi Leong Xavier Wong,Zhao-xiang Bian
medrxiv(2024)
Ronghui Liang,Zi-Wei Ye,Zhenzhi Qin,Yubin Xie, Xiaomeng Yang,Haoran Sun,Qiaohui Du, Peng Luo,Kaiming Tang,Bodan Hu,Jianli Cao,Xavier Hoi-Leong Wong,
Nature Communicationsno. 1 (2024): 1-15
Nature communicationsno. 1 (2023): 4986
NATURE METABOLISMno. 2 (2022): 203-212
Basic Gastroenterology (2022): A33-A37
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