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个人简介
Trained as a dentist, Dr. Xuesong He started his academic career by studying bacterial pathogenicity at the single species and duo-species level. Dr. He made significant contributions towards the better understanding of the regulation of virulence factors in some of the main oral pathogens, including the cariogenic bacterium Streptococcus mutans, and periodontal pathogen, Fusobacterium nucleatum.
In the past few years, with the explosion of our knowledge in the diversity and complexity of host-associated microbiome, as well as the increased appreciation of their crucial role in human health, Dr. He has expanded his research interests to tackle the new challenges in the host-associated microbiome, particularly oral microbiome research.
He has a broad background in Microbiology, particularly oral microbiology with comprehensive knowledge of microbial genetics, cell-cell communication and microbial ecology and microbial-host interaction. Some of his research interests include: 1) Understanding the interaction between the newly discovered human oral epiparasitic nanobacteria and their bacterial host; 2) Using novel culturing methods to isolate and study the physiology and pathogenesis of thus far “uncultivated” oral bacteria, including Candidate Phyla Radiation group within oral cavity; 3) Understanding the ecological and social aspects of host-associated microbiome, 4) Investigating the role of host-tRNA derived small RNA (tsRNA) in modulating host-oral microbial interaction. Dr. He is the contact PI of multiple active R01 grants from NIH. The national and international impact of Dr. He’s research can be proved by his over 60 well-cited publications in peer-reviewed leading scientific journals including PNAS, PLOS Pathogens, ISME J, Journal of Endodontics, Journal of Dental Research, Trends in Microbiology.
In the past few years, with the explosion of our knowledge in the diversity and complexity of host-associated microbiome, as well as the increased appreciation of their crucial role in human health, Dr. He has expanded his research interests to tackle the new challenges in the host-associated microbiome, particularly oral microbiome research.
He has a broad background in Microbiology, particularly oral microbiology with comprehensive knowledge of microbial genetics, cell-cell communication and microbial ecology and microbial-host interaction. Some of his research interests include: 1) Understanding the interaction between the newly discovered human oral epiparasitic nanobacteria and their bacterial host; 2) Using novel culturing methods to isolate and study the physiology and pathogenesis of thus far “uncultivated” oral bacteria, including Candidate Phyla Radiation group within oral cavity; 3) Understanding the ecological and social aspects of host-associated microbiome, 4) Investigating the role of host-tRNA derived small RNA (tsRNA) in modulating host-oral microbial interaction. Dr. He is the contact PI of multiple active R01 grants from NIH. The national and international impact of Dr. He’s research can be proved by his over 60 well-cited publications in peer-reviewed leading scientific journals including PNAS, PLOS Pathogens, ISME J, Journal of Endodontics, Journal of Dental Research, Trends in Microbiology.
研究兴趣
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MICROORGANISMSno. 1 (2024)
Pu-Ting Dong,Jing Tian, Koseki J. Kobayashi-Kirschvink,Lujia Cen, Jeffrey S. McLean,Batbileg Bor,Wenyuan Shi,Xuesong He
ISME JOURNALno. 1 (2024)
biorxiv(2024)
Archives of Oral Biology (2024): 105990-105990
Jing Tian, Bingqian Zhao,Jingyan Wang,Wenbin Du,Wenli Ma,Bin Xia,He Xu,Tsute Chen,Xuesong He,Man Qin
INTERNATIONAL JOURNAL OF PAEDIATRIC DENTISTRY (2024)
JOURNAL OF ORAL MICROBIOLOGYno. 1 (2024): 2287349-2287349
Himanshi Tanwar, Jeba Mercy Gnanasekaran,Devon Allison,Ling-shiang Chuang,Xuesong He,Mario Aimetti,Giacomo Baima,Massimo Costalonga,Raymond K. Cross,Cynthia Sears,Saurabh Mehandru,Judy Cho,
JOURNAL OF CROHNS & COLITIS (2024)
Qiu Zhong,Binyou Liao, Jiazhen Liu,Wei Shen,Jing Wang, Leilei Wei,Yansong Ma,Pu-Ting Dong,Batbileg Bor, Jeffrey S. McLean,Yunjie Chang,Wenyuan Shi,
Himanshi Tanwar, Jeba Mercy Gnanasekaran, Devon Allison,Ling-Shiang Chuang,Xuesong He,Mario Aimetti,Giacomo Baima,Massimo Costalonga,Raymond K Cross,Cynthia Sears,Saurabh Mehandru,Judy Cho,
Journal of Crohn's & colitis (2024)
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