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Research Abstract
We study the molecular mechanisms that control T cell and NK cell function in the tumor microenvironment, with a particular focus on the pathways that constrain their effector function. We also study the mechanisms that enable tumor cells to resist an attack by T cells or NK cells. Our strategy integrates investigation of the immune system in human tumors with in-depth mechanistic investigation in model systems. We embrace the complexity of the human cancers and their interaction with the immune system as an opportunity to discover novel biology that opens new perspectives for cancer treatment. Of particular interest are strategies that are relevant for multiple cancer types. We hope to inspire advances in cancer treatment that harness the power of the immune system.
Research Interests
Papers共 416 篇Author StatisticsCo-AuthorSimilar Experts
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期刊级别
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合作机构
NATURE CELL BIOLOGY (2024)
Reference Module in Life Sciences (2024)
Francesca Alvarez Calderon,Byong H Kang,Oleksandr Kyrysyuk,Shiwei Zheng, Hao Wang,Nathan D Mathewson,Adrienne M Luoma, Xiaohan Ning,Jason Pyrdol, Xuan Cao,Mario L Suvà,Guo-Cheng Yuan,
Bloodno. 12 (2024): 1124-1138
Elisha R. Verhaar, Anouk Knoflook,Novalia Pishesha,Xin Liu, Willemijn J. C. van Keizerswaard,Kai W. Wucherpfennig,Hidde L. Ploegh
FRONTIERS IN IMMUNOLOGY (2024): 1368586-1368586
Nature cell biologyno. 5 (2024): 841-841
Ye Zhao,Kai W Wucherpfennig
Current opinion in oncologyno. 3 (2024): 136-142
crossref(2023)
crossref(2023)
CELL REPORTSno. 12 (2023): 113564-113564
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Author Statistics
#Papers: 414
#Citation: 36350
H-Index: 92
G-Index: 187
Sociability: 8
Diversity: 0
Activity: 3
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