His immunology research includes (1) the elucidation of cytokine and chemokine network and intracellular signal transductions of immune effector cells including eosinophils, lymphocytes, mast cells, basophils and dendritic cells in inflammatory diseases, with recent emphasizing in pattern recognition receptors mediated innate immunity and immunoregulatory cytokines, (2) the immunopathological mechanisms of allergic diseases, autoimmune diseases, infectious diseases and diabetes mellitus, with interdepartmental collaboration and (3) the immunomodulatory, anti-tumor and anti-allergic activities of traditional Chinese medicine. High-throughput immunoassay, flow cytometry, mass cytometry, molecular technology, proteomic method and transgenic murine model have been applied in above studies. He has published 260 refereed papers in international journals and book chapters (Web of Science Core Collection, H-index = 51).