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Major Research Interests
Our research is focussed on the molecular analysis of normal human variability and genetic disturbances of development and differentiation.
Isolated genes are being analysed in detail with respect to their functional properties by animal models (transgenic and knock-out-mice). For suitable genetic diseases therapeutic strategies (substitution; gene therapy) are being developed and initial evaluation of such strategies is done in the mouse. - We are working on the genotype – phenotype correlations in neurological and cardiovascular diseases (e. g. Spastic paraplegia, Rett syndrome, Morbus Osler, mental retardation by subtelomeric microdeletions, molybdenum cofactor deficiency; cardiomypathies, Noonan syndrome) and several genetically determined malformation syndromes. We are also engaged in the molecular and cellular basis of initiation events of cancer, specifically in prostate cancer, medulloblastoma and rhabdomyosarcoma. - One main interest in our institute is the analysis of structure, expression and function of genes involved in differentiation of male gametes. The knowledge of the function of those genes can help us to clarify the genetic causes of male infertility.
We have isolated spermatogonial stem cells (SSCs) from adult mouse testis and demonstrated that these cells are as pluripotent as embryonic stem cells (ESCs). Our main interest is now to isolate and proliferate SSCs from adult human testis. These cells would be of great interest for regenerative medicine.
Our research is focussed on the molecular analysis of normal human variability and genetic disturbances of development and differentiation.
Isolated genes are being analysed in detail with respect to their functional properties by animal models (transgenic and knock-out-mice). For suitable genetic diseases therapeutic strategies (substitution; gene therapy) are being developed and initial evaluation of such strategies is done in the mouse. - We are working on the genotype – phenotype correlations in neurological and cardiovascular diseases (e. g. Spastic paraplegia, Rett syndrome, Morbus Osler, mental retardation by subtelomeric microdeletions, molybdenum cofactor deficiency; cardiomypathies, Noonan syndrome) and several genetically determined malformation syndromes. We are also engaged in the molecular and cellular basis of initiation events of cancer, specifically in prostate cancer, medulloblastoma and rhabdomyosarcoma. - One main interest in our institute is the analysis of structure, expression and function of genes involved in differentiation of male gametes. The knowledge of the function of those genes can help us to clarify the genetic causes of male infertility.
We have isolated spermatogonial stem cells (SSCs) from adult mouse testis and demonstrated that these cells are as pluripotent as embryonic stem cells (ESCs). Our main interest is now to isolate and proliferate SSCs from adult human testis. These cells would be of great interest for regenerative medicine.
研究兴趣
论文共 192 篇作者统计合作学者相似作者
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Jae Ho Lee,Cornelia Jung, Parisa Javadian-Elyaderani,Stefan Schweyer, Dorothea Schütte,Moneef Shoukier,Feridoun Karimi-Busheri,Michael Weinfeld,Aghdass Rasouli-Nia,Jan G. Hengstler,Alejandra Mantilla,Hamid Reza Soleimanpour-Lichaei,
crossref(2023)
Jae Ho Lee,Cornelia Jung, Parisa Javadian-Elyaderani,Stefan Schweyer, Dorothea Schütte,Moneef Shoukier,Feridoun Karimi-Busheri,Michael Weinfeld,Aghdass Rasouli-Nia,Jan G. Hengstler,Alejandra Mantilla,Hamid Reza Soleimanpour-Lichaei,
crossref(2023)
Jae Ho Lee,Cornelia Jung, Parisa Javadian-Elyaderani,Stefan Schweyer, Dorothea Schütte,Moneef Shoukier,Feridoun Karimi-Busheri,Michael Weinfeld,Aghdass Rasouli-Nia,Jan G. Hengstler,Alejandra Mantilla,Hamid Reza Soleimanpour-Lichaei,
crossref(2023)
Jae Ho Lee,Cornelia Jung, Parisa Javadian-Elyaderani,Stefan Schweyer, Dorothea Schütte,Moneef Shoukier,Feridoun Karimi-Busheri,Michael Weinfeld,Aghdass Rasouli-Nia,Jan G. Hengstler,Alejandra Mantilla,Hamid Reza Soleimanpour-Lichaei,
crossref(2023)
TISSUE ANTIGENSno. 1 (2014): 5-5
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