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个人简介
My research focuses on anti-cancer drug design using synthetic organic chemistry as the main tool. Tetrahydroisoquinoline derivatives with excellent physicochemical properties were developed as a new class of microtubule disruptors showing very good activity against various cancer cells lines including some taxane-resistant ones.
One of our most potent compound to date, STX3451 could also provide a new approach for inducing cell death and lowering tumour burden in NF1 and other hormone responsive cancers with limited treatment options. More recently, my research focus has shifted towards the synthesis of anti-bacterial compounds and inositol adenophostin derivatives.
One of our most potent compound to date, STX3451 could also provide a new approach for inducing cell death and lowering tumour burden in NF1 and other hormone responsive cancers with limited treatment options. More recently, my research focus has shifted towards the synthesis of anti-bacterial compounds and inositol adenophostin derivatives.
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论文共 56 篇作者统计合作学者相似作者
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Bioorganic & Medicinal Chemistry (2024): 117645-117645
Ylana Adami Franco, Manoel Oliveira de Moraes Jr,Larissa A. C. Carvalho,Wolfgang Dohle,Renaira Oliveira da Silva,Isabella Harumi Yonehara Noma,Keli Lima,Barry V. L. Potter,Joao A. Machado-Neto,Silvya Stuchi Maria-Engler
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCESno. 14 (2023): 11314-11314
Leon Hosang, Anke Löhndorf,Wolfgang Dohle,Anette Rosche,Stephen Marry,Björn-Philipp Diercks,Lukas C. Müller-Kirschbaum, Lioba T. Flügel,Barry V.L. Potter,Francesca Odoardi,Andreas H. Guse,Alexander Flügel
Biochimica et Biophysica Acta (BBA) - Molecular Cell Researchno. 6 (2023): 119485-119485
Hanan S Anbar, Nisha Yarifbhai Vahora, Hajra Laghman Shah, Mariyam Mohammed Azam, Tamanna Islam,Fatima Hersi,Hany A Omar,Wolfgang Dohle,Barry V L Potter,Mohammed I El-Gamal
European journal of pharmacology (2023): 176119-176119
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ChemMedChemno. 23 (2022)
Anke Löhndorf,Leon Hosang,Wolfgang Dohle,Francesca Odoardi, Sissy-Alina Waschkowski,Anette Rosche,Andreas Bauche,Riekje Winzer,Eva Tolosa,Sabine Windhorst,Stephen Marry,Alexander Flügel,
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