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个人简介
My research is concerned with enzymes that catalyze unusual reactions. These investigations involve the purification of unknown enzymes, the study of their respective mechanisms and the synthesis of synthetic enzyme models. The focus on active site analogues evolved because catalytic systems can be created displaying reactivity comparable to the enzymes, and intermediates of the reaction cycles can be synthesized which have escaped detection so far. Provided these synthetic intermediates are structurally well characterized and kinetically competent this wisdom is likely to be useful to identify the corresponding intermediates at the protein. This research at the interface of organic chemistry, biochemistry, and inorganic chemistry finally provides information which often can not be obtained from investigating the proteins itself and hence is a step forward to understand how nature catalyzes sophisticated reactions.
研究兴趣
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CHIMIA International Journal for Chemistryno. 7-8 (2014): 575-577
Cheminformno. 5 (2010)
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作者统计
#Papers: 133
#Citation: 3784
H-Index: 36
G-Index: 57
Sociability: 5
Diversity: 3
Activity: 0
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