基本信息
views: 76
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
Bio
Research Focus
Protein misfolding and human disease
Conversion of genetic information into functional protein products requires the proper folding of polypeptide chains in the crowded intracellular environment. Disruption of these folding pathways through exposure to either environmental or genetic factors is associated with numerous human diseases – collectively referred to as protein misfolding diseases. Using proteomic, biophysical and cell biological approaches, work in the Wiseman lab is directed towards understanding the physical, chemical and biological factors that dictate intracellular protein folding as it relates to human disease. Currently, we have three ongoing projects focused on protein folding in vivo: 1) development of novel biosensors that report on protein folding in the complex intracellular environment; 2) characterization of mitochondrial folding efficiency in the context of neurodegenerative disease; and 3) elucidation of the impact of intracellular signaling pathways on protein folding and trafficking in the early secretory pathway.
Protein misfolding and human disease
Conversion of genetic information into functional protein products requires the proper folding of polypeptide chains in the crowded intracellular environment. Disruption of these folding pathways through exposure to either environmental or genetic factors is associated with numerous human diseases – collectively referred to as protein misfolding diseases. Using proteomic, biophysical and cell biological approaches, work in the Wiseman lab is directed towards understanding the physical, chemical and biological factors that dictate intracellular protein folding as it relates to human disease. Currently, we have three ongoing projects focused on protein folding in vivo: 1) development of novel biosensors that report on protein folding in the complex intracellular environment; 2) characterization of mitochondrial folding efficiency in the context of neurodegenerative disease; and 3) elucidation of the impact of intracellular signaling pathways on protein folding and trafficking in the early secretory pathway.
Research Interests
Papers共 149 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Christoph Hofmann, Marjan Aghajani, Cecily D Alcock,Erik A Blackwood,Clara Sandmann,Nicole Herzog,Julia Groß,Lars Plate,R Luke Wiseman,Randal J Kaufman,Hugo A Katus,Tobias Jakobi,
Journal of molecular and cellular cardiology (2024): 12-24
Caroline Stanton, Chavin Buasakdi, Jie Sun, Ian Levitan, Prerona Bora,Sergei Kutseikin,R Luke Wiseman,Michael J Bollong
bioRxiv : the preprint server for biology (2024)
Thierry Touvier,Francesca A. Veneri,Anke Claessens,Cinzia Ferri,Rosa Mastrangelo, Noémie Sorgiati,Francesca Bianchi, Serena Valenzano,Ubaldo Del Carro,Cristina Rivellini,Phu Duong,Michael E. Shy,
bioRxiv the preprint server for biology (2024)
Caroline Stanton, Jie Sun, Kayla Nutsch, Jessica D. Rosarda, Thu Nguyen, Chloris Li-Ma, Evert Njomen, Bruno Melillo, Sergei Kutseikin, Enrique Saez, Benjamin F. Cravatt, John R. Teijaro,
Kelsey R Baron, Samantha Oviedo, Sophia Krasny,Mashiat Zaman, Rama Aldakhlallah, Prakhyat Mathur,Gerald Pfeffer,Michael J Bollong,Timothy Shutt,Danielle A Grotjahn,R Luke Wiseman
bioRxiv : the preprint server for biology (2024)
crossref(2023)
Journal of Immunologyno. 1 (2023): 77.06-77.06
biorxiv(2023)
Load More
Author Statistics
#Papers: 144
#Citation: 7748
H-Index: 45
G-Index: 87
Sociability: 6
Diversity: 3
Activity: 64
Co-Author
Co-Institution
D-Core
- 合作者
- 学生
- 导师
Data Disclaimer
The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn