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职业迁徙
个人简介
The original aim of Thilly’s research group was to discover the origins of disease-causing mutations in humans. They developed the first quantitative human cell mutation assays (1976), two independent means to measure mutations in human tissues (1983-93), and a protocol to scan mutations in human organs and populations 1996.
Then in 2002 -08 his lab discovered that point mutations in human tissues arise in “metakaryotic” stem cells of the fetal juvenile organs mediated by “unforced errors” of DNA polymerases gamma and beta. Now they have discovered that ds RNA/DNA intermediates are used in genome replication in fetal organogenic and adult cancer stem cells.
Research Areas:
Carcinogenesis
Computational Modeling
Systems Biology
Toxicology
研究兴趣
论文共 162 篇作者统计合作学者相似作者
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Zeinab Taki,Elena Gostjeva,William Thilly, Bodoor Yaseen,Henry Lopez, Maria Mirza, Zainab Hassuji,Shivanee Vigneswaran,Bahja Ahmed Abdi, Amy Hart,Nikita Arumalla,Gemma Thomas,
Edward C Kirkpatrick,Michael E Mitchell,William G Thilly, Pip Hidestrand,Aoy Tomita-Mitchell, Mats Hidestrand,Elena V Gostjeva
Elena V. Gostjeva,Vera V. Koledova,Liyuan Bai, Kailin C. Duan,Tushar Kamath, Meghan Nelson,Parul Agnihotri, Deborah J. Moshinski, Li Ping Wu,Lawrence Zukerberg,Daniel C. Chung,Susan Tsai,
Issues in Toxicology (2016): 196-249
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