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The human adrenal cortex acts as a compound endocrine gland that secretes mineralocorticoids, glucocorticoids and the so-called adrenal androgens. These steroids arise from distinct zone of the adrenal cortex that have both morphologic and biochemical differences. Neither the origin of the stem cells of the cortical zones nor the mechanisms leading to the zone-specific production of steroids is clearly defined. The functional zonation of the adrenal cortex can be traced to the zone-specific expression of the enzymes involved in steroid biosynthesis. Here we take the novel approach of focusing on the molecular mechanisms that regulate the development of a glomerulosa, fasiculata or reticularis phenotype. We propose to define the mechanisms that regulate adrenal cell expression of key enzymes that directly impact the ability of adrenal cells to produce aldosterone, cortisol or DHEA-S. The proposed studies will provide insight into the normal physiology of the adrenal as well as pathologies associated with dysregulation of adrenal steroids.
The human adrenal cortex acts as a compound endocrine gland that secretes mineralocorticoids, glucocorticoids and the so-called adrenal androgens. These steroids arise from distinct zone of the adrenal cortex that have both morphologic and biochemical differences. Neither the origin of the stem cells of the cortical zones nor the mechanisms leading to the zone-specific production of steroids is clearly defined. The functional zonation of the adrenal cortex can be traced to the zone-specific expression of the enzymes involved in steroid biosynthesis. Here we take the novel approach of focusing on the molecular mechanisms that regulate the development of a glomerulosa, fasiculata or reticularis phenotype. We propose to define the mechanisms that regulate adrenal cell expression of key enzymes that directly impact the ability of adrenal cells to produce aldosterone, cortisol or DHEA-S. The proposed studies will provide insight into the normal physiology of the adrenal as well as pathologies associated with dysregulation of adrenal steroids.
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Typhanie Dumontet, Katie Basham, Micah Foster, Kyle Heard,Christopher Lapensee,Christina Bothou,Felix Beuschlein,William Rainey,Adina F. Turcu,Antonio Lerario,Gary Hammer
Endocrine Abstracts (2024)
FRONTIERS IN ENDOCRINOLOGY (2024): 1286297-1286297
MOLECULAR AND CELLULAR ENDOCRINOLOGY (2024): 112176-112176
Hypertension (Dallas, Tex. : 1979)no. 7 (2023): 1555-1567
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Cancer researchno. 13 (2023): 2123-2141
Journal of the Endocrine Societyno. Supplement_1 (2023)
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Journal of the Endocrine Societyno. Supplement_1 (2023)
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