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个人简介
Description of Research Expertise
Research Interests
Control of cerebral hemodynamics during physiologic and pathologic conditions such as traumatic brain injury, stroke, and cerebral ischemia/reperfusion.
Research Techniques
Closed cranial window for measurement of pial artery diameter and collection of cortical periarachnoid CSF for vasoactive metabolite concentration determination by RIA, fluid percussion brain injury, global cerebral ischemia, photothrombotic cerebral injury, radiolabelled microsphere regional cerebral blood flow determination.
Research Summary
Dr. Armstead's research focuses on characterizing mechanisms important in the control of cerebral hemodynamics under physiologic and pathologic conditions such as traumatic brain injury (TBI), stroke, and cerebral hypoxia/ischemia, particularly in the newborn. Current projects focus on interactions between the NMDA receptor and plasminogen activators after TBI, optimizing the efficacy/toxicity ratio of tPA, the only FDA approved treatment for stroke and translational research concerning the roles of sex and age in outcome after pediatric TBI.
Key Words
tPA, adrenomedullin, newborn, brain injury, stroke, endothelin, nitric oxide, cerebral circulation
Research Interests
Control of cerebral hemodynamics during physiologic and pathologic conditions such as traumatic brain injury, stroke, and cerebral ischemia/reperfusion.
Research Techniques
Closed cranial window for measurement of pial artery diameter and collection of cortical periarachnoid CSF for vasoactive metabolite concentration determination by RIA, fluid percussion brain injury, global cerebral ischemia, photothrombotic cerebral injury, radiolabelled microsphere regional cerebral blood flow determination.
Research Summary
Dr. Armstead's research focuses on characterizing mechanisms important in the control of cerebral hemodynamics under physiologic and pathologic conditions such as traumatic brain injury (TBI), stroke, and cerebral hypoxia/ischemia, particularly in the newborn. Current projects focus on interactions between the NMDA receptor and plasminogen activators after TBI, optimizing the efficacy/toxicity ratio of tPA, the only FDA approved treatment for stroke and translational research concerning the roles of sex and age in outcome after pediatric TBI.
Key Words
tPA, adrenomedullin, newborn, brain injury, stroke, endothelin, nitric oxide, cerebral circulation
研究兴趣
论文共 73 篇作者统计合作学者相似作者
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JOURNAL OF NEUROTRAUMAno. 16 (2018): A57-A57
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JOURNAL OF NEUROTRAUMAno. 13 (2016): A28-A28
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Journal of Neurotraumano. 22 (2013): 1898-1907
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