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The research carried out in this laboratory is directed toward elucidating the mechanism of action of drugs of abuse with emphasis on the opioids. The major emphasis has been placed on the study of the underlying mechanisms of opioid tolerance and physical dependence. Methodologies employed in this laboratory include behavioral techniques such as classical pharmacological procedures to measure pain and its alleviation, quantitation of blood flow using laser Doppler methods and sophisticated neurochemical procedures such as the use of HPLC to separate endogenous opioids, measurements of endogenous neuropeptides and second messengers via radioimmunoassay of free intracellular calcium levels in cells using whole-cell imaging, as well as microfluorimetric techniques.
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论文共 118 篇作者统计合作学者相似作者
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Research square (2023)
Boshi Huang,Mengchu Li, Pornprom Klongkumnuankarn,Rolando E Mendez,James C Gillespie,David L Stevens,William L Dewey,Dana E Selley,Yan Zhang
Mengchu Li,David L. Stevens, Michelle Arriaga,E. Andrew Townsend,Rolando E. Mendez, Nadejda A. Blajkevch,Dana E. Selley,Matthew L. Banks,S. Stevens Negus,William L. Dewey,Yan Zhang
Advances in drug and alcohol research (2022)
Salvador Sierra,Karan H Muchhala,Donald K Jessup,Katherine M Contreras,Urjita H Shah,David L Stevens, Jennifer Jimenez, Xiomara K Cuno Lavilla,Mario de la Fuente Revenga,Kumiko M Lippold,Shanwei Shen,Justin L Poklis,
Neuropharmacology (2022): 108988-108988
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