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个人简介
Dr. Polacheck’s laboratory investigates the physical interactions between cells and their environment and how forces at the cellular scale contribute to tissue development, homeostasis, and disease. To study how cells sense and generate forces in living tissue, the Polacheck lab develops microfluidic technology to build microtissues in the laboratory that mimic the architecture and multicellular function of human tissues in vivo. By integrating these organ-on-chip models with genome editing, induced-pluripotent stem cell technology, and other cell and molecular biology techniques, the Polacheck lab has developed a novel approach for understanding the molecular machinery employed by cells to generate force sand to transduce forces from their environment into biological responses. The lab seeks to leverage these biological insights to inform novel drug targets for diseases in which misregulation of cellular forces contribute to pathogenesis, such vascular disease, cancer, and fibrosis. Furthermore, the lab works to translate the technology and techniques developed to build microtissues into tissue engineered therapies for organ replacement and regenerative medicine.
Research Interests
Mechanobiology
Microfluidics
Cardiovascular Tissue Engineering
Dynamics of Biofluids
研究兴趣
论文共 71 篇作者统计合作学者相似作者
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Gregory Farber,Yanhan Dong,Qiaozi Wang,Mitesh Rathod,Haofei Wang, Michelle Dixit,Benjamin Keepers,Yifang Xie, Kendall Butz,William J Polacheck,Jiandong Liu,Li Qian
Nature communicationsno. 1 (2024): 4170-4170
BIOFABRICATIONno. 1 (2024)
Chloe P. Whitworth,Wen Y. Aw,Elizabeth L. Doherty,Chenchen Handler,Yogeshwari Ambekar, Aanya Sawhney,Giuliano Scarcelli,William J. Polacheck
Cellular and Molecular Bioengineeringpp.1-17, (2024)
EXPERT OPINION ON DRUG DISCOVERYno. 3 (2024): 339-351
Matthew J. Rich, Sarah Burnash, Rohan R. Krishnan,Susan Chubinskaya,Richard F. Loeser,William J. Polacheck,Brian O. Diekman
JOURNAL OF BIOMECHANICS (2024): 111887-111887
Mitesh L. Rathod,Wen Yih Aw,Stephanie Huang,Jingming Lu,Elizabeth L. Doherty, Chloe P. Whithworth, Gang Xi,Prabir Roy-Chaudhury,William J. Polacheck
SMALLno. 24 (2024): e2307901-e2307901
Elizabeth L. Doherty, Grace Krohn,Emily C. Warren, Alexandra Patton,Chloe P. Whitworth,Mitesh Rathod,Andreea Biehl,Wen Yih Aw,Donald O. Freytes,William J. Polacheck
ADVANCED HEALTHCARE MATERIALSpp.e2400192-e2400192, (2024)
Journal of the American Society of Nephrologyno. 11S (2023): 726-726
biorxiv(2023)
Proceedings of the National Academy of Sciences of the United States of Americano. 41 (2023): e2308941120-e2308941120
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