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The spread or metastasis of cancer is ultimately responsible for most cancer deaths. New drugs employing unique mechanisms are needed to improve therapy of these advanced cancers. New biologic treatments based on functional changes in the extracellular matrix during cancer progression represent a novel approach. TIMPs are a small family of low molecular weight proteins first identified as endogenous metalloproteinase inhibitors. However, these proteins also modulate growth, migration and invasion of both normal and tumor cells. TIMP-2 inhibits tumor growth and metastasis in animal models independent of its protease inhibitor activity. TIMP-2 is under development as a new biologic therapy for cancer.
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AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGYno. 3 (2024): C917-C934
Matrix Biology Plus (2024): 100156
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David Peeney,Sadeechya Gurung, Josh Rich, Sasha Coates-Park,Yueqin Liu, Jack Toor, Jane Jones, Christoper Richie,Lisa Jenkins,William Stetler-Stevenson
Research square (2024)
Sasha Coates-Park,Carolyn Lazaroff,Sadeechya Gurung, Josh Rich, Alexandra Colladay, Maura O'Neill,Georgina S Butler,Christopher M Overall,William G Stetler-Stevenson,David Peeney
Matrix biology : journal of the International Society for Matrix Biology (2023): 59-70
The American journal of pathologyno. 10 (2023): 1336-1352
David Peeney,Sarvesh Kumar,Tej Pratap Singh,Yueqin Liu, Sandra M Jensen,Ananda Chowdhury, Sasha Coates-Park, Joshua Rich,Sadeechya Gurung,Yu Fan,Daoud Meerzaman,William G Stetler-Stevenson
bioRxiv : the preprint server for biology (2023)
Cancer Researchno. 7_Supplement (2023): 4695-4695
CANCER RESEARCHno. 12 (2022)
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David Peeney,Sadeechya Gurung,Yueqin Liu,Carolyn Lazaroff, Christopher Richie,William G. Stetler-Stevenson
Cancer Researchno. 12_Supplement (2022): 3836-3836
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