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Research
A Nobel Prize was awarded for the discovery of the physiological role of nitric oxide and NO was named the 1992 “Molecule of the Year” by Science magazine. The Frazier lab discovered that CD47 is a receptor for thrombospondin-1 and that TSP1 ligation of CD47 negates the beneficial effects of NO signaling thereby exacerbating all cardiovascular diseases. We are now studying the molecular details of the TSP1-CD47 binding interaction, the mechanism of CD47 inhibition of NO signaling and discovering new phenotypes of CD47-null mice.
Research Interest
Regulation of angiogenesis and integrin function.
研究兴趣
论文共 118 篇作者统计合作学者相似作者
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crossref(2023)
METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND MATERIALS SCIENCEno. 9 (2023): 3461-3475
JOURNAL OF NUCLEAR MATERIALS (2023): 154271-154271
Applied Sciencesno. 5343 (2023): 5343-5343
crossref(2023)
COMPUTATIONAL MATERIALS SCIENCE (2023): 112386-112386
TMS 2022 151ST ANNUAL MEETING & EXHIBITION SUPPLEMENTAL PROCEEDINGSpp.705-712, (2022)
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