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The primary focus of the research in my laboratory is to understand the molecular pathogenesis of cerebral small vessel diseases (CSVDs), particularly cerebral amyloid angiopathy (CAA). These efforts include the generation and characterization of rodent models for CAA, mechanisms and biological functions of cerebral amyloid assembly, pathological progression of disease, diagnosis and intervention. With a strong training in protein biochemistry and cell biology, over the years my laboratory has expanded our expertise to include molecular biology, molecular pathology, and the generation of numerous transgenic, gene knock out, and gene mutation knock in mouse and rat models to study in vivo functions of APP, pathogenic amyloid formation in the CNS and its contributions to vascular cognitive impairment and dementia (VCID). These areas have largely defined our research. My laboratory is recognized as a pioneering group in the experimental study of CAA and vascular amyloid asembly and has contributed significant scientific progress in this discipline. Previously, we generated novel transgenic mice, and more recently, novel transgenic rats that specifically develop CAA, in the absence of brain parenchymal plaque amyloid. My laboratory is focused on generating and improving preclinical models of CSVDs since largely they are our platforms for unraveling pathogenesis, biomarker development and therapeutic testing. We have been refining protein mass spectrometry techniques in my laboratory to reveal unique regional proteomic changes that occur in our transgenic rat model of CAA, which has provided new opportunities for identifying biomarkers for the disease and mechanistic insight.
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Feng Xu,Ziao Fu, Sharmila Dass, AnnMarie E Kotarba,Judianne Davis, Steven O Smith,William E Van Nostrand
Nature communicationsno. 1 (2024): 6089-6089
Cellular and molecular life sciences : CMLSno. 1 (2024): 239-239
Acta Neuropathologica Communicationsno. 1 (2024): 6-6
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