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个人简介
My research interest is the study of effects of chemicals on the nervous system, particularly those chemicals which act directly on the synapse. My primary research interest is in the cellular mechanism of action of chemicals which disrupt Ca2+-dependent processes at the membrane and intracelluarly. A variety of techniques including electrophysiological recordings of ion channel activity (patch-voltage clamp) and synaptic transmission (intracellular and extracellular microelectrode recording techniques), neurochemical analysis of synaptic function and fluorescent microscopy and digital imaging of intracellular ion concentrations using fluorescent probes such as Fura-2. Toxicological research interests are presently focused on the effects of heavy metals such as methylmercury, many of which exert potent toxic actions at chemical synapses, and on the potential interaction of environmental toxicants with diseases in the cardiovascular and nervous systems. An additional area of research is in neuroscience, and is directed at understanding mechanism of neuronal damage associated with human motor neuron and neuromuscular diseases- especially identifying the molecular entities involved in Ca2+-dependent neurosecretion.
研究兴趣
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NEUROTOXICOLOGY (2024): 72-84
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