基本信息
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职业迁徙
个人简介
Clinical Specialties: Eye Diagnostics & Surgery
Clinical and Teaching activities:
Dr. Beltran is a board-certified veterinary ophthalmologist. He consults at the Ryan Veterinary Hospital of the University of Pennsylvania, and teaches clinical ophthalmology to veterinary students.
Research Areas: Ophthalmology, Retinal Degeneration, Retinal remodeling, Gene therapy, Photoreceptor cell death
Description of Research Expertise
Retinal degeneration, photoreceptor cell death, light-induced retinal damage, retinal remodeling, neuroprotection, gene therapy, optogenetics.
Keywords: Retinal degeneration, X-linked RP, RPGR, autosomal dominant RP, rhodopsin, light damage, CNTF.
Inherited retinal degenerations constitute a major cause of blindness in dogs and humans worldwide, and share a common feature: the degeneration and death of the photoreceptor cells. Although a significant number of genes associated with retinitis pigmentosa (RP) have been identified, there is currently no treatment available.
Dr. Beltran’s research is focused at examining the cellular and molecular mechanisms of photoreceptor death in canine models of retinal degeneration, and developing novel therapeutic approaches aimed at curing or slowing the progression of this group of diseases in dogs and human patients.
Studies currently conducted in Dr. Beltran’s laboratory include:
1) Investigating the signaling pathways of cell death in canine models of X-linked RP caused by mutations in the RPGR gene.
2) Elucidating the pathogenesis of light-induced retinal degeneration in the T4R rhodopsin mutant dog, a model of human autosomal dominant RP.
3) Testing neuroprotective agents for their potential photoreceptor rescue properties.
4) Developing and testing corrective gene therapy approaches for RPGR-XLRP, and RHO-ADRP in collaboration with the Aguirre (Univ. Penn), Jacobson and Cideciyan (Univ. Penn),Hauswirth and Lewin (Univ. Florida) laboratories.
5) Testing optogenetic tools as a potential strategy for recovering visual function in patients with late stages of retinal degeneration.
Clinical and Teaching activities:
Dr. Beltran is a board-certified veterinary ophthalmologist. He consults at the Ryan Veterinary Hospital of the University of Pennsylvania, and teaches clinical ophthalmology to veterinary students.
Research Areas: Ophthalmology, Retinal Degeneration, Retinal remodeling, Gene therapy, Photoreceptor cell death
Description of Research Expertise
Retinal degeneration, photoreceptor cell death, light-induced retinal damage, retinal remodeling, neuroprotection, gene therapy, optogenetics.
Keywords: Retinal degeneration, X-linked RP, RPGR, autosomal dominant RP, rhodopsin, light damage, CNTF.
Inherited retinal degenerations constitute a major cause of blindness in dogs and humans worldwide, and share a common feature: the degeneration and death of the photoreceptor cells. Although a significant number of genes associated with retinitis pigmentosa (RP) have been identified, there is currently no treatment available.
Dr. Beltran’s research is focused at examining the cellular and molecular mechanisms of photoreceptor death in canine models of retinal degeneration, and developing novel therapeutic approaches aimed at curing or slowing the progression of this group of diseases in dogs and human patients.
Studies currently conducted in Dr. Beltran’s laboratory include:
1) Investigating the signaling pathways of cell death in canine models of X-linked RP caused by mutations in the RPGR gene.
2) Elucidating the pathogenesis of light-induced retinal degeneration in the T4R rhodopsin mutant dog, a model of human autosomal dominant RP.
3) Testing neuroprotective agents for their potential photoreceptor rescue properties.
4) Developing and testing corrective gene therapy approaches for RPGR-XLRP, and RHO-ADRP in collaboration with the Aguirre (Univ. Penn), Jacobson and Cideciyan (Univ. Penn),Hauswirth and Lewin (Univ. Florida) laboratories.
5) Testing optogenetic tools as a potential strategy for recovering visual function in patients with late stages of retinal degeneration.
研究兴趣
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bioRxiv : the preprint server for biologyno. 1 (2024): 18-18
Leonardo Murgiano, Jessica K. Niggel,Leontine Benedicenti, Matteo Cortellari,Arianna Bionda, Paola Crepaldi,Luigi Liotta, Geoffrey K. Aguirre,William A. Beltran,Gustavo D. Aguirre
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCEno. 8 (2023)
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William A. Beltran,Ana Ripolles-Garcia,Yu Sato, Alexandra Gray,John H. Wolfe,Agustin Luz-Madrigal, Michael J. Philipps,David M. Gamm,Geoffrey K. Aguirre,Gustavo D. Aguirre
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCEno. 8 (2023)
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PHARMACEUTICSno. 12 (2022): 2711
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