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Our research program focuses on the discovery and design of new antibiotics and natural products. These projects combine synthetic organic and protein chemistry to address problems at the interface of chemistry and biology.
Numerous reports of multi-drug resistant bacterial strains have appeared in recent years, with several strains posing the threat of becoming immune against all commercially available antibiotics. It is evident that in order to prevent potential epidemic outbreaks of infectious diseases, a renewed focus on antibiotic research is highly desired, including the search for new drugs with alternative cellular targets, the investigation of the mechanisms of cytotoxicity and resistance, and the understanding of biosynthetic pathways. Unfortunately, at this time of critical need for new antimicrobial agents, the large pharmaceutical companies have almost entirely withdrawn from this area due to small projected profits. The van der Donk group focuses on the mode of action and mechanism of biosynthesis of two classes of antibiotics that have been underexplored but have great potential for human therapeutic use, lantibiotics and phosphonate antibiotics.
2021 Member of the National Academy of Sciences
2020 Harrison Howe Awardee
2020 Pedler Award, the Royal Society of Chemistry
2017 Repligen Award, American Chemical Society
2017 Vincent du Vigneaud Award, American Peptide Society
2016 NIGMS Merit Award, NIH
2015 Bioorganic Chemistry Award, Royal Society of Chemistry
2014 Member of the American Academy of Arts and Sciences
2013 Emil Thomas Kaiser Award, The Protein Society
2012 Fellow of the American Association for the Advancement of Science
2011 Fellow of the American Academy of Microbiology
Numerous reports of multi-drug resistant bacterial strains have appeared in recent years, with several strains posing the threat of becoming immune against all commercially available antibiotics. It is evident that in order to prevent potential epidemic outbreaks of infectious diseases, a renewed focus on antibiotic research is highly desired, including the search for new drugs with alternative cellular targets, the investigation of the mechanisms of cytotoxicity and resistance, and the understanding of biosynthetic pathways. Unfortunately, at this time of critical need for new antimicrobial agents, the large pharmaceutical companies have almost entirely withdrawn from this area due to small projected profits. The van der Donk group focuses on the mode of action and mechanism of biosynthesis of two classes of antibiotics that have been underexplored but have great potential for human therapeutic use, lantibiotics and phosphonate antibiotics.
2021 Member of the National Academy of Sciences
2020 Harrison Howe Awardee
2020 Pedler Award, the Royal Society of Chemistry
2017 Repligen Award, American Chemical Society
2017 Vincent du Vigneaud Award, American Peptide Society
2016 NIGMS Merit Award, NIH
2015 Bioorganic Chemistry Award, Royal Society of Chemistry
2014 Member of the American Academy of Arts and Sciences
2013 Emil Thomas Kaiser Award, The Protein Society
2012 Fellow of the American Association for the Advancement of Science
2011 Fellow of the American Academy of Microbiology
研究兴趣
论文共 26 篇作者统计合作学者相似作者
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Dinh T Nguyen,Lingyang Zhu, Danielle L Gray, Toby J Woods, Chandrashekhar Padhi, Kristen M Flatt,Douglas A Mitchell,Wilfred A van der Donk
ACS central scienceno. 5 (2024): 1022-1032
Current Opinion in Chemical Biology (2024): 102467-102467
biorxiv(2023)
biorxiv(2023)
Yanhui Zheng, Xiaoqing Xu, Xiaoli Fu,Xuerong Zhou,Chao Dou,Yue Yu,Weizhu Yan, Jingyuan Yang,Minqin Xiao,Wilfred A van der Donk,Xiaofeng Zhu,Wei Cheng
Structure (London, England : 1993)no. 10 (2023): 1220-1232.e5
Zhenrun J. Zhang,Chunyu Wu, Darian Dorantes, Téa Pappas,Anitha Sundararajan,Huaiying Lin, Eric G. Pamer,Wilfred A. van der Donk
biorxiv(2023)
Annual review of biochemistry (2022): 269-294
Cell chemical biologyno. 12 (2021): 1740-1749.e6
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